Astrocytes Give Rise to New Neurons in the Adult Mammalian Hippocampus

By Bettina Seri, Jose Manuel García-Verdugo, Bruce S. McEwen, Arturo Alvarez-Buylla. 2001

1,601 citations recorded by the source corpus.

Subfields: Cancer Research, Developmental Neuroscience, Neurology

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Citations in the corpus

Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults (2018, neutral): “(3) In accordance with institutional guidelines and study design approval by the Institutional Review Board (Ethics Committee) of Shanghai Medical College (20110307085, 20120302-099).”
Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions (2011, background): “adult SVZ and SGZ, quiescent radial glia-like cells are rapidly activated to support continuous neurogenesis after eliminating rapidly proliferating progeny with AraC treatment (Doetsch et al., 1999; Seri et al., 2001).”
BRAIN REGENERATION IN PHYSIOLOGY AND PATHOLOGY: THE IMMUNE SIGNATURE DRIVING THERAPEUTIC PLASTICITY OF NEURAL STEM CELLS (2011, background): “The new hippocampal neurons are born in the SGZ, which is located at the interface of the granule cell layer and the hilus, and in contrast to the extensive tangential migration undertaken by olfactory bulb neurons, hippocampal granule neurons move only a short distance into the granule cell layer (”
Neurogenesis in the Adult Hippocampus. (2015, background): “They express astrocytic marker GFAP and intermediate filament nestin, but not the calcium-binding protein S100β, which is expressed in a distinct postmitotic astrocytic population (Seri et al. 2001; Steiner et al. 2004).”
Brain tumour stem cells (2006, background): “There is a similar hierarchical neurogenetic system in the subgranular zone of rodent”
Adult neurogenesis: from precursors to network and physiology. (2005, methodology): “According to work carried out in Alvarez-Buylla's laboratory (501), the stemlike cells may correspond to a subpopulation of GFAP-positive cells, equivalent to the type B cells described in the SVZ, since 2 h after their birth a large majority of newly born cells express GFAP (501).”
Type‐2 cells as link between glial and neuronal lineage in adult hippocampal neurogenesis (2006, background): “Type-1 cells might constitute the largely quiescent population of stem cells that can replenish the pool of transiently amplifying progenitor cells (Seri et al., 2001, 2004).”
The glial identity of neural stem cells (2003, background): “The SGZ contains SGZ astrocytes (B cells) and ultrastructurally dark GFAP-negative D cell”
Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain (2008, background): “Indeed, proliferating astroglial cells in specific brain regions act as adult neural stem cells (11, 12), and a dedifferentiation of astrocytes toward earlier developmental stages, such as in the postnatal (13) or embryonic brain (14), may have obvious implications for the attempts to reconstitute n”
Reversible effect of X‐irradiation on proliferation, neurogenesis, and cell death in the dentate gyrus of adult mice (2007, positive): “This suggests that slowly dividing and quiescent cells, which have been identified in the proliferative matrix of the dentate gyrus (Seri et al., 2001; Steiner et al., 2006), are relatively radioresistant, providing a reserve pool for the replenishment of the cell population after 1 week.”
Milestones of neuronal development in the adult hippocampus. (2004, background): “From data by Seri et al., it seems likely that this intermediate cell also originates from the radial-glia-like precursor [ 19 ] but final proof of their multipotency in vivo is still lacking.”
Functional significance of adult neurogenesis. (2004, background): “In both systems, the stem cells appear to be cells with astrocytic properties [1,2].”