Neurogenesis may relate to some but not all types of hippocampal‐dependent learning

By T. Shors, D. Townsend, Mingrui Zhao, Y. Kozorovitskiy, E. Gould. 2002

914 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Developmental Neuroscience, Neurology

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In Developmental Neuroscience

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Citations in the corpus

New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? (2010, background): “For example, the ablation of adult neurogenesis in rats by methylazoxymethanol acetate (MAM) treatment results in deficits in hippocampus-dependent trace conditioning tasks but not in hippocampus-independent delay conditioning task”
Environmental enrichment and neurogenesis: from mice to humans (2015, background): “In some cases, MAM treatment of rats during EE impaired performance in object recognition memory and a trace fear conditioning paradigm, but not contextual fear conditioning or spatial navigation learning in the MWM [41,42].”
Computational influence of adult neurogenesis on memory encoding. (2009, neutral): “…impaired performance on the Morris water maze (Dupret et al., 2008; Snyder et al., 2005; Zhang et al., 2008), but no differences in water maze performance were seen in several other studies using different (and in one case the same) knockdown techniques (Saxe et al., 2006; Shors et al., 2002).”
Structural Plasticity and Hippocampal Function (2010, background): “…been shown that a disruption of hippocampal neurogenesis, either by using irradiation or antimitotic drugs, enhances susceptibility to stress (Surget et al. 2008) or induces depression-like or anxietyrelated behaviors (Airan et al. 2007, Santarelli et al. 2003, Saxe et al. 2006, Shors et al. 2002).”
Potential role for adult neurogenesis in the encoding of time in new memories (2006, background): “Consistent with the idea that neurogenesis may not be required for all dentate gyrus functions, experiments that repress neurogenesis have generally failed to show the same short-term acquisition deficits that dentate gyrus lesions sho”
Adult-born hippocampal neurons are more numerous, faster-maturing and more involved in behavior in rats than in mice (2009, background): “…function by 4 weeks of age (Snyder et al., 2005; Winocur et al., 2006; Wojtowicz et al., 2008) and, in several cases, as young as 2–3 weeks of age (Shors et al., 2001; Snyder et al., 2001; Shors et al., 2002; Madsen et al., 2003; Schmidt-Hieber et al., 2004; Bruel-Jungerman et al., 2005).”
Methylazoxymethanol acetate does not fully block cell genesis in the young and aged dentate gyrus (2005, methodology): “For this purpose, we used MAM at a dose described as substantially and reliably reducing cell genesis (7 mg ⁄ kg; Shors et al., 2002) and at two higher doses (10 mg ⁄ kg, 14 mg ⁄ kg).”
Mechanisms and functional implications of adult neurogenesis. (2008, neutral): “…any defects in spatial learning in animals with reduced or abolished neurogenesis (Madsen et al., 2003; Meshi et al., 2006; Saxe et al., 2006; Shors et al., 2002; Snyder et al., 2005), despite the fact that impaired long-term retention of memories was observed in irradiated rats and in tlx…”