Biodistribution, clearance, and biocompatibility of iron oxide magnetic nanoparticles in rats.
By T. Jain, M. K. Reddy, M. Morales, D. Leslie-Pelecky, V. Labhasetwar. Molecular Pharmaceutics, 2008
674 citations recorded by the source corpus.
Subfields: Biomaterials, Hematology, Oncology
View Paper: https://www.semanticscholar.org/paper/d85b8c5fe9f2d2d4045e5e7ed3b5ea756692b16f
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In Biomaterials
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In Hematology
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Citations in the corpus
- NanoGenotoxicology: the DNA damaging potential of engineered nanomaterials. (2009, background): “This derivitisation of iron oxide plays an important role in internalisation efficiency and cytotoxicity [96–98].”
- Nanoparticles as drug delivery systems (2012, background): “They also cause transient increase of ALT (serum alanine aminotransferase), AST (aspartate aminotransferase), and ALP (alkaline phosphatase) levels [66].”
- Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers (2012, positive): “For instance, 55% of the intravenous dose of SPIONs coated with Pluronics/oleic acid with a hydrodynamic diameter of 193 nm was shown to accumulate in the rat liver.(73) On the other hand, SPIONs with dextran as the coating material have been reported to undergo 18%–22% elimination via the urine and”
- The shape effect of mesoporous silica nanoparticles on biodistribution, clearance, and biocompatibility in vivo. (2011, methodology): “ALT and AST are commonly used as biochemical markers for liver function.(42) The activity of ALT and AST”
- Magnetic nanoparticles for theragnostics (2009, background): “Signs of oxidative stress, evident in spleen and to a lesser degree kidney and liver of rats after intravenous administration of oleic acidpluronic-coated iron oxide MNPs, gradually declined after 3 days of administration [126].”
- Alternative Antimicrobial Approach: Nano-Antimicrobial Materials (2015, background): “investigated the in vivo behavior of SPION in rat liver and concluded that it did not influence liver function or induce oxidative stress [151].”
- Clearance Properties of Nano-sized Particles and Molecules as Imaging Agents: Considerations and Caveats (2008, background): “As a result, the rate of iron oxide metabolism in the liver is assumed to be a function of the dose injected, percent initially taken up and the cellular distribution in the liver [72,75].”