Alternative Antimicrobial Approach: Nano-Antimicrobial Materials

By N. Beyth, Y. Houri‐Haddad, A. Domb, Wahid Khan, Ronen Hazan. Evidence-Based Complementary and Alternative Medicine, 2015

771 citations recorded by the source corpus.

Despite numerous existing potent antibiotics and other antimicrobial means, bacterial infections are still a major cause of morbidity and mortality. Moreover, the need to develop additional bactericidal means has significantly increased due to the growing concern regarding multidrug-resistant bacterial strains and biofilm associated infections. Consequently, attention has been especially devoted to new and emerging nanoparticle-based materials in the field of antimicrobial chemotherapy. The present review discusses the activities of nanoparticles as an antimicrobial means, their mode of action, nanoparticle effect on drug-resistant bacteria, and the risks attendant on their use as antibacterial agents. Factors contributing to nanoparticle performance in the clinical setting, their unique properties, and mechanism of action as antibacterial agents are discussed in detail.

Subfields: Biomedical Engineering, Materials Chemistry, Organic Chemistry

View Paper: https://www.semanticscholar.org/paper/4c16bf97529f5edd7eb030c3e92fbaeb0599da72

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In Organic Chemistry

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Citations in the corpus

• Nano-Strategies to Fight Multidrug Resistant Bacteria—“A Battle of the Titans” (2018, methodology): “Besides the broad-spectrum antibacterial properties that NPs have against Gram-positive and -negative bacteria, NPs have been used as vectors for the delivery of antimicrobial moieties that greatly improve their biocidal properties (Beyth et al., 2015; Rai A. et al., 2016; Singh J. et al., 2016; Esm”
• Face Masks in the New COVID-19 Normal: Materials, Testing, and Perspectives (2020, background): “Very recently, they have been demonstrated to be effective against the newly emerged 2019 coronavirus (COVID-19), which is threatening the whole world [175, 190].”
• Emerging Strategies to Combat ESKAPE Pathogens in the Era of Antimicrobial Resistance: A Review (2019, background): “Metal nanoparticles have wide biomedical applications as antimicrobial agents due to their unique physical and chemical properties (Beyth et al., 2015; Hemeg, 2017).”
• Biofilms in the Food Industry: Health Aspects and Control Methods (2018, background): “…2016 DNAses Coughlan et al., 2016 Steel coatings Nanoparticles (Ag2+, Fe3O4, TiO2, ZnO, CuO, MgO Alteration of bacterial membrane Alexander, 2009; Beyth et al., 2015; Rai et al., 2015 Repelling surfaces (monolayers, hydrogels, modified topography) Inhibition of bacterial binding Campoccia et…”
• The antimicrobial activity of nanoparticles: present situation and prospects for the future (2017, background): “16 In addition, nanomaterials can complement and support traditional antibiotics “as a good carrier.””