The shape effect of mesoporous silica nanoparticles on biodistribution, clearance, and biocompatibility in vivo.

By Xinglu Huang, Linlin Li, Tianlong Liu, Nanjing Hao, Huiyu Liu, Dong Chen, Fangqiong Tang. ACS Nano, 2011

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Mesoporous silica nanoparticles in target drug delivery system: A review (2015, neutral): “[30] The paracellular delivery of insulin across an intestinal Caco-2 cell monolayer using micro fabricated PSi particles was one of the first examples of drug delivery using this material.”
Mesoporous silica nanoparticles in medicine--recent advances. (2013, background): “demonstrated that particle shape also influence biodistribution [23].”
Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers (2012, positive): “Moreover, short-rod mesoporous silica nanoparticles showed rapid clearance rates via urine and feces compared with long-rod mesoporous silica nanoparticles.(12) Another reason which may favor a longer blood circulation time for rod-shaped nanoparticles may be the fact that the phagocytic activity of”
Sol-gel based materials for biomedical applications (2016, background): “From this brief history, a clear development in the sol–gel approach to the production of TiO2 NPs can be seen.”
Mesoporous Silica Nanoparticles: A Comprehensive Review on Synthesis and Recent Advances (2018, background): “Hence stringent control of the shape of MSNs is important to regulate its excretion and other effects in vivo [132].”