The role of IL-6 and STAT3 in inflammation and cancer.

By D. Hodge, E. Hurt, W. Farrar. European Journal of Cancer, 2005

984 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/d82c95b4ac0c902163b05766634e86b31defa3be

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Citations in the corpus

Interleukin-6 dependent survival of multiple myeloma cells involves the Stat3-mediated induction of microRNA-21 through a highly conserved enhancer. (2007, neutral): “Stat3, the major mediator of IL-6 signaling,(1,2) participates in cellular transformation and oncogenesis.(3,4) Its activation is essential for the transforming potential of many oncogenes.”
Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB. (2007, background): “Thus, STAT3 is an oncogene, promoting cell proliferation and survival (Haura et al. 2005; Hodge et al. 2005).”
Inflammation, a Key Event in Cancer Development (2006, background): “It is well known that cytokines can activate STAT family transcription factors by the signaling of Janusactivated kinases (199).”
Immunity, Inflammation, and Cancer (2010, background): “IL-6 is of particular importance, as it acts both in paracrine and autocrine manners, and IL-6-deficient mice are resistant to induction of multiple myeloma (Hodge et al., 2005).”
Chronic Inflammation and Cytokines in the Tumor Microenvironment (2014, background): “Similarly, IL-6 promotes angiogenesis by activating the STAT3 pathway in cervical cancer [161].”
Tumor self-seeding by circulating cancer cells (2009, methodology): “of immune and inflammatory responses and have been implicated in tumor progression (Hodge et al., 2005; Kishimoto, 2005).”
Associations of Depression With C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis (2009, background): “This result is consistent with evidence that CRP influences the initiation and progression of atherosclerosis (14 –16) and IL-6 promotes several cancers (21,22).”
IL-6 and STAT3 are required for survival of intestinal epithelial cells and development of colitis associated cancer (2009, background): “…associated with underlying chronic inﬂammation, IL-6 produced by epithelial and cancer cells may still contribute to tumorigenesis in models without an obvious inﬂammatory component (Ancrile et al., 2007; Gao et al., 2007; Grivennikov and Karin, 2008; Hodge et al., 2005; Sansone et al., 2007).”
IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland. (2007, background): “Introduction IL-6, a major mediator of the inflammatory response, plays a primary role in the pathophysiology of cancer (1, 2).”
Immunostimulatory effect of Aloe vera (Aloe barbadensis) on non-specific immune response, immune gene expression, and experimental challenge with Saprolegnia parasitica in rainbow trout (Oncorhynchus mykiss) (2019, neutral): “IL-6 is known as a strong inflammatory cytokine and a mediator of physiological functions (Hodge et al., 2005).”
IL-6 Overexpression Induces Pulmonary Hypertension (2008, background): “Furthermore, in the presence of TGF- /BMP proteins, c-myc expression 8 is attenuated contributing to PASMC apoptosis.(13) How the c-myc/max complex may be 9 altering its target cell cycle genes and whether the additional stress of hypoxia may alter 10 its effects on downstream targets is unclear at ”