Chronic Inflammation and Cytokines in the Tumor Microenvironment

By G. Landskron, M. De la Fuente, P. Thuwajit, C. Thuwajit, M. Hermoso. Journal of Immunological Research, 2014

1,653 citations recorded by the source corpus.

Acute inflammation is a response to an alteration induced by a pathogen or a physical or chemical insult, which functions to eliminate the source of the damage and restore homeostasis to the affected tissue. However, chronic inflammation triggers cellular events that can promote malignant transformation of cells and carcinogenesis. Several inflammatory mediators, such as TNF-α, IL-6, TGF-β, and IL-10, have been shown to participate in both the initiation and progression of cancer. In this review, we explore the role of these cytokines in important events of carcinogenesis, such as their capacity to generate reactive oxygen and nitrogen species, their potential mutagenic effect, and their involvement in mechanisms for epithelial mesenchymal transition, angiogenesis, and metastasis. Finally, we will provide an in-depth analysis of the participation of these cytokines in two types of cancer attributable to chronic inflammatory disease: colitis-associated colorectal cancer and cholangiocarcinoma.

Subfields: Cancer Research, Pharmacology, Surgery

View Paper: https://www.semanticscholar.org/paper/81d155c5a4c3357b2812420e3aebad31f980afcd

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Citations in the corpus

• The role of ubiquitination in tumorigenesis and targeted drug discovery (2020, background): “As an important risk factor for malignancy, chronic immune activation and inflammation persistently promote TME formation by providing inflammatory mediators such as TNF-α, IL1β, IL-6 and TGF-β and ultimately lead to angiogenesis and antitumor immunity.(225,226) Ubiquitination, a ubiquitous PTM in c”
• Role of interleukin-6 in cancer progression and therapeutic resistance (2016, background): “Since inflammation enhances the growth and progression of gastrointestinal tumours via the activation of IL-6-mediated STAT-3 signalling, it appears that there is a strong link between IL-6, inflammation and tumour promotion [1, 117, 118].”