Dietary Gut Microbial Metabolites, Short-chain Fatty Acids, and Host Metabolic Regulation

By Mayu Kasubuchi, Sae Hasegawa, Takero Hiramatsu, A. Ichimura, I. Kimura. Nutrients, 2015

812 citations recorded by the source corpus.

During feeding, the gut microbiota contributes to the host energy acquisition and metabolic regulation thereby influencing the development of metabolic disorders such as obesity and diabetes. Short-chain fatty acids (SCFAs) such as acetate, butyrate, and propionate, which are produced by gut microbial fermentation of dietary fiber, are recognized as essential host energy sources and act as signal transduction molecules via G-protein coupled receptors (FFAR2, FFAR3, OLFR78, GPR109A) and as epigenetic regulators of gene expression by the inhibition of histone deacetylase (HDAC). Recent evidence suggests that dietary fiber and the gut microbial-derived SCFAs exert multiple beneficial effects on the host energy metabolism not only by improving the intestinal environment, but also by directly affecting various host peripheral tissues. In this review, we summarize the roles of gut microbial SCFAs in the host energy regulation and present an overview of the current understanding of its physiological functions.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/871de2ddf0d1a50e4d5e6fb590308e7efabd3d0e

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In Molecular Biology

1. Jeroen Raes
2. Severine Vermeire
3. K. Machiels
4. K. Verbeke
5. Sarah Deleu

In Physiology

1. Jeroen Raes
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Citations in the corpus

• Short chain fatty acids and its producing organisms: An overlooked therapy for IBD? (2021, background): “Activation of both receptors leads to PYY and GLP 1 secretion by the L-cells, which affect several tissues including the cardiovascular system, the pancreas and the brain [24].”
• Gut Microbiome: Profound Implications for Diet and Disease (2019, background): “Short-chain fatty acids (SCFAs) have attracted considerable attention for their role in human health [28].”