Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation

By J. Pluznick, Ryan J. Protzko, Haykanush Gevorgyan, Z. Peterlin, A. Sipos, Jinah Han, Isabelle Brunet, Laxiang Wan, F. Rey, Tong Wang and 6 more. Proceedings of the National Academy of Sciences of the United States of America, 2013

1,068 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/7edef0bf99e0a6ab5d33a9328446e019a8f3eeca

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Citations in the corpus

Dietary Gut Microbial Metabolites, Short-chain Fatty Acids, and Host Metabolic Regulation (2015, background): “Olfactory receptor 78 (OLFR78) was identified as SCFAs in a ligand screen for orphan GPCRs [53].”
The Hologenome Concept: Human, Animal and Plant Microbiota (2014, background): “One of the factors that plays a role in achieving this effect is short-chain fatty acids, produced by gut bacteria by fermentation of nondigestible carbohydrates (fiber, resistant starch) (Satija and Hu 2012; Pluznicka et al. 2013).”
Understanding the Holobiont: How microbial metabolites affect human health and shape the immune system (2017, background): “A fourth SCFA-responsive GPCR, the olfactory receptor 51E2 (OR51E2, also known as Olfr78 in mice), is expressed by some cells of the intestinal epithelium but has not been connected to the immune system (Fleischer et al., 2015; Pluznick et al., 2013).”
The neuropharmacology of butyrate: The bread and butter of the microbiota-gut-brain axis? (2016, background): “Of note, there is another GPCR, OLFR78, which is expressed in blood vessels to regulate blood pressure and is activated by acetate and propionate but not by butyrate (Pluznick et al., 2013).”
The role of short-chain fatty acids in the interplay between gut microbiota and diet in cardio-metabolic health (2021, methodology): “Taken together, the SCFA receptors Olfr78 and FFAR3 might play an opposing role in the regulation of blood pressure, balancing each other to have a healthy blood pressure.(97) Moreover, using a Mendelian Randomization approach, Sun and coworkers(110) reported T2D may causally affect hypertension and”
Short-Chain Fatty Acids and Their Association with Signalling Pathways in Inflammation, Glucose and Lipid Metabolism (2020, background): “FFAR3 activation induces vasodilation and lowers systemic blood pressure in vascular smooth muscle cells [60,61].”