The PARP superfamily

By J. Amé, C. Spenlehauer, G. de Murcia. Bioessays, 2004

1,471 citations recorded by the source corpus.

Subfields: Electrical and Electronic Engineering, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/d6f43775b4be1786707b1332302124615ae33300

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In Electrical and Electronic Engineering

In Molecular Biology

In Oncology

Citations in the corpus

PARP inhibition: PARP1 and beyond (2010, background): “Extending the family Against this backdrop of extensive structural and functional studies on PARP1, genes encoding 16 structurally related proteins (members of the so-called PARP family) have been identified on the basis of sequence similarity with the PARP1 catalytic domai”
PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes (2017, background): “Furthermore, they suggest that PARP-14 and PARP-15 may have gone through multiple cycles of gene birth and loss, supporting the theory that they are evolving rapidly in response to viral conflicts (Daugherty et al. 2014).”
Single-strand break repair and genetic disease (2008, neutral): “SBs arising directly from disintegration of oxidized deoxyribose are primarily detected by PARP1, although contributions from other members of the PARP superfamily are possibl”
Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors (2005, background): “fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=142">PARP1 ), which was followed by the identification of several other PARP family member”
Awakening guardian angels: drugging the p53 pathway (2009, background): “In another radically different approach alterations in cellular pathways brought about by oncogenic mutations are targeted; the most dramatic example is the efficacy of the poly (ADP-ribose) polymerase (PARP) inhibitors, which inhibit DNA repair through the base excision repair pathwa”
Poly(ADP-ribose): novel functions for an old molecule (2006, background): “gov/">National Center for Biotechnology Information (NCBI; see Further Information) for human PARP homologue”
Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012 (2011, background): “Coined after Thanatos, the personification of death in Greek mythology, the term ‘parthanatos’ has been introduced to indicate a particular cell death mode involving the DNA damage-responsive enzymes poly(ADP-ribose) polymerases (PARPs), and in particular PARP1, which alone accounts for more than 90”
The expanding field of poly(ADP-ribosyl)ation reactions. ‘Protein Modifications: Beyond the Usual Suspects' Review Series (2008, background): “…family members to 17 (Fig 2)—has considerably extended the field of study of this protein modification, which occurs only in non-yeast eukaryotes (amé et al, 2004; Otto et al, 2005; Schreiber et al, 2006). it remains to be determined whether all parp family members can effectively synthesize…”
The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets (2010, neutral): “The primary nuclear PARPs are PARP-1, PARP2 (the closest paralog to PARP-1), PARP-3, and tankyrases 1 and 2 (PARP-5a and -5b) (Ame et al., 2004; Hakme et al., 2008; Hassa and Hottiger, 2008; Schreiber et al., 2006).”
PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration (2010, background): “PARP-1 is an abundant nuclear enzyme with approximately 1-2 million copies in the cell which account for ~85% of total cellular PARP activity [31-34].”