The expanding field of poly(ADP-ribosyl)ation reactions. ‘Protein Modifications: Beyond the Usual Suspects' Review Series

By A. Hakmé, H. Wong, F. Dantzer, V. Schreiber. EMBO Reports, 2008

626 citations recorded by the source corpus.

Poly(ADP‐ribosyl)ation is a post‐translational modification of proteins that is mediated by poly(ADP‐ribose) polymerases (PARPs). Although the existence and nature of the nucleic acid‐like molecule poly(ADP‐ribose) (PAR) has been known for 40 years, understanding its biological functions—originally thought to be only the regulation of chromatin superstructure when DNA is broken—is still the subject of intense research. Here, we review the mechanisms controlling the biosynthesis of this complex macromolecule and some of its main biological functions, with an emphasis on the most recent advances and hypotheses that have developed in this rapidly growing field.

Subfields: Immunology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/06a46fa800f76133328c284d43ec9c566495b5d5

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In Immunology

1. W. Kraus
2. Ivan Dikic
3. Raga Krishnakumar

In Molecular Biology

1. Ivan Dikic
2. S. Polo
3. W. Kraus
4. Raga Krishnakumar
5. Stephen P. Jackson
6. V. Kirkin
7. Beth Levine
8. R. Youle

In Oncology

1. W. Kraus
2. S. Polo
3. Raga Krishnakumar
4. Stephen P. Jackson
5. Ivan Dikic
6. Yosef Shiloh

Citations in the corpus

• A role for ubiquitin in selective autophagy. (2009, background): “In addition, HSPs interact with Ub E3 ligases, such as CHIP and Parkin (Imai et al., 2002), which Molecular Cell 34, May 15, 2009 ª2009 Elsevier Inc. 259 2 6 0 M o le c u la r C e ll 3 4 , M a y 1 5 , 2 0 0 9 ª 2 0 0 9 E ls e v ie r In c . ties of Yeast and Human Autophagy-Specific UBLs in Compariso”
• Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications. (2011, background): “PARylation targets DDR proteins to DNA breaks The covalent modification of proteins with ADP-ribose polymers, a process known as PARylation, is catalyzed by PARP enzymes (Hakme et al. 2008).”
• The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets (2010, positive): “Dynamic Synthesis and Degradation of PAR PAR is synthesized rapidly in response to a variety of physiological (e.g., hormone signaling) and stress-related (e.g., heat shock, DNA damage) stimuli (D’Amours et al., 1999; Hakme et al., 2008).”