Poly(ADP-ribose): novel functions for an old molecule

By V. Schreiber, F. Dantzer, J. Amé, G. Murcia. Nature reviews. Molecular cell biology, 2006

1,959 citations recorded by the source corpus.

Subfields: Electrical and Electronic Engineering, Oncology, Physiology

View Paper: https://www.semanticscholar.org/paper/b506205eaab4b29e46c678db915f64b38e4d605c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Electrical and Electronic Engineering

In Oncology

In Physiology

Citations in the corpus

Age Related Changes in NAD+ Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats (2011, background): “The DNA damage associated with oxidative stress is known to activate the NAD-dependent DNA repair enzyme, PARP, which assists in combination with the enzymes of the baseexcision-and-repair complex of the cell in energy-consuming repair processes [12,52,53].”
The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets (2010, positive): “, 2008, 2010), a nuclear localization signal (NLS), and a caspase-3 cleavage site (Hakme et al., 2008; Schreiber et al., 2006).”
The expanding field of poly(ADP-ribosyl)ation reactions. ‘Protein Modifications: Beyond the Usual Suspects' Review Series (2008, background): “…homeostasis has been described in several recent in-depth reviews, and is therefore only briefly mentioned here (Hsiao & Smith, 2008; Kraus, 2008; Schreiber et al, 2006). par is a crucial regulator of the DNa-damage response that involves the SSBr/BEr pathway. parp1 activation by DNa breaks…”
The NAD+/sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling (2013, background): “…PARP1 and PARP2 representing the main PARP activities in mammals—were classically described as DNA repair proteins (Gibson and Kraus, 2012; Schreiber et al., 2006), but recent studies have linked these proteins to metabolism (Asher et al., 2010; Bai et al., 2011a, 2011b; Erener et…”
Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells (2008, background): “The first ADP-ribose is usually added to the γ-carboxyl residue of Glu in acceptor proteins [148].”
Regulation of poly(ADP-Ribose) polymerase 1 functions by post-translational modifications. (2018, positive): “PARP1, which has many protein binding partners in the nucleus, has been identified as a component of a variety of protein complexes, including those that (1) repair DNA damage, (2) regulate transcription, (3) function as insulators, (4) methylate DNA, and (5) promote iPSC reprograming (8–21).”
Chapter 1. General introduction (2015, positive): “22 1 a substrate in order to modulate various cellular processes by poly(ADP)ribosylation (82).”