Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors

By P. Jagtap, C. Szabó. Nature reviews. Drug discovery, 2005

909 citations recorded by the source corpus.

Subfields: Electrical and Electronic Engineering, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/cb570dd54a2b33b911d3826b6c11b8babe09c8b0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Electrical and Electronic Engineering

1. W. Kraus
2. Raga Krishnakumar

In Molecular Biology

1. T. Chan-Ling
2. J. Amé
3. Nektarios Tavernarakis
4. M. Hottiger
5. Rafael Radi
6. P. Hassa
7. W. Kraus
8. Raga Krishnakumar

In Oncology

1. M. Hottiger
2. P. Hassa
3. C. Szabó
4. W. Kraus
5. Raga Krishnakumar

Citations in the corpus

• Poly(ADP-ribose): novel functions for an old molecule (2006, background): “They also showed that it participates detrimentally in inflammatory diseases by inducing cell death in the injured tissue”
• Age Related Changes in NAD+ Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats (2011, background): “Recent studies have shown the protective effects of PARP inhibitors on ischaemic heart and liver, diabetic kidney disease, and endotoxin-induced acute lung injury, arguably due to the preservation of NAD levels [20,21,22,23,24].”
• Crosstalk between apoptosis, necrosis and autophagy. (2013, background): “As already mentioned earlier, PARP1 belongs to a family of nuclear enzymes, modulating DNA repair, transcriptional regulation, chromatin modi fi cation and genomic stability through polyADP-ribosylation [131,132].”
• The expanding field of poly(ADP-ribosyl)ation reactions. ‘Protein Modifications: Beyond the Usual Suspects' Review Series (2008, background): “…2007; yu et al, 2006). parp1–/– mice and mice treated with parp inhibitors show protection from tissue injury and organ failure in various oxidative stress-related disease models— such as acute and chronic inflammatory diseases or ischaemia—and neurodegenerative disorders ( Jagtap & Szabo, 2005).”
• Peroxynitrite: biochemistry, pathophysiology and development of therapeutics (2007, background): “Amplification of peroxynitrite-mediated mitochondrial toxicity may also involve amplification mechanisms involving extramitochondrial pathways, including the nuclear enzyme poly(ADP-ribose) polymerase (PARP”
• The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases. (2008, background): “Moreover, studies performed exclusively with poly-ADP-ribosylation/PARP inhibitors will not be addressed in this review due to the off-target effects of poly-ADP-ribosylation inhibitors and nonspecific inhibition of both poly-ADP-ribosylation and certain mono-ADP-ribosylation reactions (33-35).”