PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes

By Rebecca Gupte, Ziying Liu, W. Kraus. Genes & Development, 2017

639 citations recorded by the source corpus.

In this review, Gupte et al. discuss new findings on the diverse roles of PARPs in chromatin regulation, transcription, RNA biology, and DNA repair as well as recent advances that link ADP-ribosylation to stress responses, metabolism, viral infections, and cancer.

Subfields: Immunology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/457f2070350b9321e17f288bdf0d41daeb8e4a4c

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Citations in the corpus

• NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential (2020, background): “PARPs catalyze reversible ADP-ribosylation of macromolecular targets including proteins, DNA and RNA, utilizing NAD as a cofactor to provide monomer or polymers of ADP-ribose nucleotide.(27,28) PARP members can be categorized into several groups, the poly-ADP-ribosyl transferases (e.”
• Therapeutic potential of NAD-boosting molecules: the in vivo evidence (2018, neutral): “Some PARPs are mono-ADP-ribose transferases, so a better name for these proteins is MARTs (Bai, 2015; Gupte et al., 2017).”