TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway.

By G. Takaesu, S. Kishida, Atsushi Hiyama, Kyoko Yamaguchi, H. Shibuya, K. Irie, J. Ninomiya-Tsuji, K. Matsumoto. Molecules and Cells, 2000

633 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/d699d4c40caa730bf06cc5792c2d5e2e08668042

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Citations in the corpus

MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells (2009, background): “Both, Pellino-1 and TAB2 are part of a molecular complex containing the TNF receptor-associated factor 6 (TRAF6) and allow activation of the inflammatory response upon TLR4 or IL-1 receptor triggering (29, 30).”
Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update. (2012, background): “IIID4) leading to autophosphorylation at the classical Thr180/Tyr182 activating phosphoacceptor sites (FIGURE 3).”
Lipopolysaccharide signaling in endothelial cells (2006, background): “72 while TAB2 links TAK1 to TRAF6 and facilitates the ubiquitination of TRAF6”
NFκB-dependent signaling pathways (2002, background): “The three proteins TAK1/TAB1/TAB2 have been implicated in linking TRAF6 to IKK in IL-1–mediated signaling [80–85].”
The Interleukin-1 Receptor/Toll-Like Receptor Superfamily: Signal Transduction During Inflammation and Host Defense (2000, background): “TRAF-6 interacts with TAB-2, and this complex activates TGF-β-activated kinase (TAK)-1 (133).”
Toll-like receptor-mediated NF-kappaB activation: a phylogenetically conserved paradigm in innate immunity. (2001, background): “NIK, on the other hand, can be phosphorylated and activated by TGF-β–activated kinase 1 (TAK1), which binds to TRAF6 through the binding proteins TAB1 and TAB2 (33, 34).”
mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6 (2013, methodology): “(d) HEK293 cells were co-transfected with vectors encoding AMBRA1 together with ULK1–Myc FL (full length) or its deletion mutants encoding the kinase and the proline-rich domains (1829–1,051), and the ULK1 carboxy-terminal domain (11-828).”
TAK1 is a ubiquitin-dependent kinase of MKK and IKK (2001, methodology): “Here we report the purification and identification of TRIKA2, which is composed of TAK1, TAB1 and TAB2, a protein kinase complex previously implicated in IKK activation through an unknown mechanis”
Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma. (2007, background): “To explore the roles of specific signaling adaptor proteins in LPS activation and transrepression, we investigated TAB2, which plays a cytoplasmic role in TLR4-dependent signal transduction and is also a component of a subset of NCoR complexes (Baek et al., 2002; Jiang et al., 2004; Takaesu et al., ”