Immunity, Inflammation, and Allergy in the Gut

By T. Macdonald, G. Monteleone. Science, 2005

1,113 citations recorded by the source corpus.

Subfields: Immunology, Surgery

View Paper: https://www.semanticscholar.org/paper/d554d042a95d00ebd459074c719eb4fd4e61d16f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. F. Powrie
2. D. Cua
3. Wenjun Ouyang
4. D. Artis
5. Nicolas Buchon
6. K. Maloy
7. Yan Zheng
8. Brent S. McKenzie

In Surgery

1. Wenjun Ouyang
2. D. Artis
3. Yan Zheng
4. S. Bischoff
5. Ted G. Dinan
6. J. Cryan

Citations in the corpus

• Systems medicine: the future of medical genomics and healthcare (2009, background): “Other important contextual phenomena that also need to be taken into account in future studies include the effects of the mother’s genetic makeup or feeding habits on the development of the fetus and the timing of its biological clock, which have been observed in animal models [224,225], and the cen”
• Mucosal vaccines: the promise and the challenge (2006, background): “In the intestine, where bacteria are abundant, epithelial cells, together with intraepithelial lymphocytes and underlying phagocytic cells, can modulate and dampen these signals to prevent undesirable responses to non-threatening nutrients and the normal intestinal flora that could lead to mucosal i”
• Development of the Human Infant Intestinal Microbiota (2007, neutral): “the host [2,5,7,18,45].”
• Chylomicrons promote intestinal absorption of lipopolysaccharides Published, JLR Papers in Press, September 24, 2008. (2009, neutral): “an important center of intestinal immunity (60).”
• Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut (2008, background): “The necessity to regulate immune responses to commensal bacteria is exemplified by evidence that dysregulation of the balance between tolerance and immunity can contribute to the pathogenesis of numerous inflammatory conditions, including food allergies, inflammatory bowel disease (IBD) and intestin”
• Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens (2008, background): “The tight junctions of intestinal epithelial cells provide the first barrier preventing microbes from leaving the intestinal lume”
• Interleukin-23 drives innate and T cell–mediated intestinal inflammation (2006, background): “A breakdown in the regulatory mechanisms that control homeostasis is thought to precipitate the dysregulated intestinal infl ammation that characterizes human infl ammatory bowel disease (IBD), including Crohn’s disease (CD) (1, 2).”
• Brain–Gut–Microbe Communication in Health and Disease (2011, background): “…(IBD), which includes the two distinct disease patterns of ulcerative colitis (UC) and Crohn’s disease (CD; Lichtenstein,2000; Blumberg and Strober,2001; Podolsky,2002; MacDonald and Monteleone, 2005), has attracted attention as a disorder with an aberrant GIT microbial signature (Shanahan, 2004).”
• Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila. (2009, background): “Interestingly, stimulation of stem cell activity by invasive bacteria is proposed to favor the development of hyperproliferative states found in precancerous lesions (Macdonald and Monteleone 2005; Radtke and Clevers 2005).”
• Pathomechanisms of Oxidative Stress in Inflammatory Bowel Disease and Potential Antioxidant Therapies (2017, background): “Previous evidence has demonstrated that the balance between the commensal microbiota in the GI tract and host mucosal immune responses plays a significant role in the pathogenesis and duration of IBD [130].”