Interleukin-10 and related cytokines and receptors.

By S. Pestka, Christopher D. Krause, D. Sarkar, M. Walter, Yufang Shi, P. Fisher. Annual Review of Immunology, 2004

1,193 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/d4eb52621d10be17daff994fd091d618b99ce2ba

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In Immunology

1. M. Karin
2. D. Artis
3. T. Lawrence
4. Jinfang Zhu
5. W. E. Paul
6. V. Nizet
7. Luigi Ferrucci
8. M. Battaglia

In Oncology

1. T. Lawrence
2. V. Nizet
3. A. Kantarcı
4. T. V. Van Dyke
5. M. Karin
6. W. E. Paul
7. M. Battaglia
8. Jinfang Zhu

Citations in the corpus

• The biological functions of T helper 17 cell effector cytokines in inflammation. (2008, neutral): “IL-22R, IL-20R1, and IL-20R2 all belong to the class II cytokine-receptor family (Pestka et al., 2004).”
• IL‐22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis (2006, background): “Interestingly, IL-10R2 is also part of the IL-10, IL-26, IL-28a/b, and IL-29 receptor complexes [ 4 ].”
• IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis. (2008, background): “IL-22 binds to a heterodimeric receptor that consists of the IL-22RA1 and IL-10R2 chains (2, 3).”
• Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation (2011, neutral): “Whereas IL-10Rα, required for ligand binding, is unique to the IL-10R complex, IL-10Rβ, essential to mediate downstream signaling, is shared between several members of the class II cytokine receptors such as IL-22R and IFN-λR family members (Pestka et al., 2004).”
• A cytokine-mediated link between innate immunity, inflammation, and cancer. (2007, neutral): “However, the effects of IL-10 are dramatically opposed to those of IL-6, as IL-10 is immunosuppressive and antiinflammatory (88).”
• How are TH2-type immune responses initiated and amplified? (2010, background): “(an epidermal growth factor family member) and IL-24 , which has antitumour effect”
• Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer. (2006, background): “IL-10 and the structurally-related type I interferons (IFNs), as well as IL-6, IL-12, and many other cytokines, signal via receptor associated TKs that belong to the JAK group, whose activation results in phosphorylation and nuclear translocation of STAT transcription factors (O’Shea et al., 2002).”
• Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22 (2011, background): “IL-22 was further classified as a class 2 α-helical cytokine of the IL-10 family of cytokines, which consists of IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26 (ref”
• Resolution of a chronic viral infection after interleukin-10 receptor blockade (2006, background): “It suppresses the function of APCs and T cells by inhibiting proinfl ammatory cytokine production, co-stimulation, MHC class II expression, and chemokine secretion (1, 2).”
• Inflammatory and immune pathways in the pathogenesis of periodontal disease (2014, background): “Interleukin-4 also induces the production of interleukin-10, another anti-inflammatory cytokine (191).”