Liver from bone marrow in humans

By N. Theise, M. Nimmakayalu, Rebekah Gardner, P. Illei, G. Morgan, L. Teperman, O. Henegariu, D. Krause. Hepatology, 2000

1,278 citations recorded by the source corpus.

Subfields: Genetics, Hepatology, Surgery

View Paper: https://www.semanticscholar.org/paper/d47411c24cd44fac2849f01631b36cc298fd103b

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Citations in the corpus

HGF, SDF-1, and MMP-9 are involved in stress-induced human CD34+ stem cell recruitment to the liver. (2003, background): “Of interest, this patient presented significant leukocytic infiltration 164 The Journal of Clinical Investigation | July 2003 | Volume 112 | Number 2 in the inflamed liver, predominantly by lymphocytes, suggesting involvement of the increased SDF-1 levels in attraction of lymphocytes to the HCV-infe”
Bone marrow contributes to renal parenchymal turnover and regeneration (2001, background): “For example, adult bone marrow cells show remarkable plasticity and may differentiate into hepatocytes [1–5], biliary epithelial cells [4], endothelial cells [6,7], skeletal muscle fibres [8], cardiomyocytes [9], and neuronal cells [10].”
Plasticity of marrow-derived stem cells. (2003, positive): “In these patients, the degree of subsequent damage to the transplanted liver correlated with the extent of male (host-derived) hepatocyte engraftment.(29)”
In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. (2003, background): “This phenomenon of engraftment of bone marrow–derived cells into multiple tissues is also found in humans (29, 30).”
Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations. (2001, background): “…of commitment to stem cells or differentiated cells for distinct organs or tissues (Ferrari et al. 1998; Bjornson et al. 1999; Gussoni et al. 1999; Gritti et al. 1996; Clarke et al. 2000; Brazelton et al. 2000; Mezey et al. 2000; Pereira et al. 1995; Petersen et al. 1999; Theise et al. 2000a,b).”
The role of hepatocytes and oval cells in liver regeneration and repopulation. (2003, background): “The generation of oval cells and hepatocytes from HSC does not generally exceed 2% (Alison et al., 2000; Petersen et al., 1999; Theise et al., 2000a).”
Multipotent mesenchymal stem cells from adult human synovial membrane. (2001, background): “Marrow cells have been reported to contribute to angiogenesis (3,4), somatic muscle development (5,6), liver regeneration (7,8), and the formation of central nervous system cell types (9,10).”
Stem cell plasticity: time for a reappraisal? (2005, positive): “Using in situ hybridization for Y-chromosome analysis, 4 to 43% hepatocytes and 4 to 38% cholangiocytes were found to be of extrahepatic origin.(49) Taken together, these studies provided the proof of principle that BM contributes to liver regeneration.”