Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations.

By Irving L. Weissman, D. Anderson, Fred H. Gage. Annual Review of Cell and Developmental Biology, 2001

1,001 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Genetics, Hematology

View Paper: https://www.semanticscholar.org/paper/3fcc9e2b529308a160fbf2ab13158b1225ab36c0

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Citations in the corpus

Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment. (2005, background): “Virtually all LT-HSC, ST-HSC, and MPP activities in adult mouse bone marrow (BM) have been shown to reside in the small Lin−Sca-1+c-kithi (LSK) HSC compartment (0.1% of all BM cells; Ikuta and Weissman, 1992; Li and Johnson, 1995; Spangrude et al., 1988; Weissman et al., 2001).”
The spleen in local and systemic regulation of immunity (2013, background): “It is well appreciated that hematopoietic stem and progenitor cells (HSPCs) exist in bone marrow niches where they produce their lineage descendants (Weissman et al., 2001).”
Epidermal stem cells of the skin. (2006, background): “C Matrix: proliferative compartment of the growing hair follicle containing progenitor cells that terminally differentiate to give rise to the hair shaft or the channel surrounding it”
Adult cardiac stem cells are multipotent and support myocardial regeneration. (2003, background): “Clusters of Primitive and Early Committed Cells in theal., 1997; Weissman et al., 2001; Kondo et al., 2003), we Heartdecided to concentrate on the cardiac cells expressing (A) Cluster of 11 c-kitPOS cells (green) with three expressing c-kitthis marker, the receptor for SCF.”
Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche. (2004, background): “Finally, when sues, including epidermis, intestine, muscle, the hemamarked rodent bulge cells are transplanted onto athymic topoetic system, and even brain (Weissman et al., 2001; mice, their progeny can be detected in the resulting Wagers and Weissman, 2004).”
In vivo clonal analysis reveals self-renewing and multipotent adult neural stem cell characteristics (2011, neutral): “Stem cells are defined by two characteristic properties: the capacity to renew themselves through mitotic cell division and the capacity to differentiate into specialized cell type(s) (Gage, 2000; Weissman et al., 2001).”
Consensus guidelines for the use and interpretation of angiogenesis assays (2018, background): “Stem and progenitor cells provide a necessary homeostatic source of tissue-specific mature cellular elements that permit appropriate cell functions through replacement of injured, diseased, and senescent cells in many organ systems throughout the life span [188].”
SSEA-1 Is an Enrichment Marker for Tumor-Initiating Cells in Human Glioblastoma (2009, background): “Similar to hematopoietic stem cells, probably the most thoroughly characterized stem cell population, a combination of markers will ultimately best define glioma TSCs/TICs (Dick, 2008; Kim et al., 2006; Weissman et al., 2001).”
Embryonic stem cells: prospects for developmental biology and cell therapy. (2005, methodology): “VIIIC), but it has been successfully employed in rodent models with a variety of stem cells isolated as primary isolates, following cultivation in vitro or following genetic modification (219, 384).”
c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation. (2004, background): “In addition to early committed precursors of all hematopoietic lineages, the lin population also contains the c-Kit (CD117) Sca-1 subpopulation highly enriched for hematopoietic stem cells (KLS-HSC) (Uchida and Weissman 1992; Weissman et al. 2001).”
Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells (2004, methodology): “In this discussion we adopted the operational definition of stem cells as the only normal cells capable of self-renewal [29,30].”
Neurogenesis in the adult brain: new strategies for central nervous system diseases. (2004, background): “Unlike the hematopoietic and the neural crest fields, where stem cells can be isolated based on surface antigens, the field of adult neural stem cells is hampered by our current inability to identify and acutely isolate them (29).”
Milestones of neuronal development in the adult hippocampus. (2004, background): “One might want to apply a classical concept of stem cell biology [ 45 ,46] to these cells and consider type-1 cells as stem cells, type-2a and type-2b cells as transiently amplifying, lineage-determined progenitor cells, and type-3 cells as neuroblasts.”