Stem cell plasticity: time for a reappraisal?

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Beta-thalassemia (2010, background): “Patients maintained on a regular transfusion regimen progressively develop clinical manifestations of iron overload: hypogonadism (35-55% of the patients), hypothyroidism (9-11%), hypoparathyroidism (4%), diabetes (610%), liver fibrosis, and heart dysfunction (33%) [35,36].”
A review of tissue-engineered skin bioconstructs available for skin reconstruction (2010, unknown): “Varying microenvironmental stimuli may affect stem cell plasticity, and result in acquiring stem cell functions by more differentiated cells and limiting stem capacity by pushing stem cells into a more differentiated state (Lemoli et al. 2005).”
A single oncogenic enhancer rearrangement causes concomitant EVI1 and GATA2 deregulation in leukemia. (2014, unknown): “Concordantly, RPN1 has therefore generally been the assumed origin of ectopic EVI1 regulatory elements, since it is located in the proximity of the chromosome 3 breakpoint cluster (Suzukawa et al., 1994; Wieser et al., 2003).”