The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages.

By P. Allavena, A. Sica, G. Solinas, C. Porta, A. Mantovani. Critical reviews in oncology/hematology, 2008

1,011 citations recorded by the source corpus.

Subfields: Immunology, Oncology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/d4297018a7c88123bca01ec36bd428d43c1555b6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. A. Mantovani
2. C. Garlanda
3. P. Allavena
4. S. Jaillon
5. G. Solinas
6. D. Gabrilovich
7. G. Germano
8. E. Tcyganov

In Oncology

1. P. Allavena
2. A. Mantovani
3. C. Garlanda
4. G. Solinas
5. R. Medzhitov
6. G. Germano
7. A. Ben-Baruch
8. E. Song

In Psychiatry and Mental health

1. P. Allavena
2. A. Mantovani
3. C. Garlanda

Citations in the corpus

• Tumor associated macrophages and neutrophils in cancer. (2013, background): “The tumor microenvironment, characterized by a chronic nflammation and consisting of various host components including tromal cells, growing blood vessels and inflammatory infiltrate, is nown to play important roles in cancer development and behavor (Allavena et al. 2008; Coussens and Werb 2002; Han”
• Tumor‐associated macrophages (TAM) as major players of the cancer‐related inflammation (2009, background): “Other factors able to influence macrophage polarization toward an M2 profile are IL10, IL-6, TGF- , and PGE2 [5, 50].”
• Mesenchymal Stem Cell Secretome: Toward Cell-Free Therapeutic Strategies in Regenerative Medicine (2017, background): “Another important cellular component of tumor microenvironment are tumor associated macrophages (TAMs) [148], which are a relevant inhibitor of anti-tumor immunity and a crucial barrier to successful immunotherapy [149].”
• Stress, Inflammation, and Defense of Homeostasis (2014, background): “Thus, pathogen sensing is primarily delegated to macrophages (Gordon, 2007), but in addition, macrophages may also play a role in sensing more generic stressors, such as hypoxia and metabolic stress (i.e., deficit or excess in key metabolites) (Allavena et al., 2008).”
• Macrophages in Tumor Microenvironments and the Progression of Tumors (2012, background): “Other chemokines, such as CCL3, CCL4, CCL5, CCL7, CCL8, CXCL12, and cytokines, including vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), and IL-10, are also reported to promote macrophage recruitment [14, 37–39].”
• Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype (2021, background): “…Biology | www.frontiersin.org 12 March 2021 | Volume 9 | Article 645593 cells can bring about durable, local and systemic effects in vivo, which promote chronic diseases and age-associated functional decline (Allavena et al., 2008; Coppé et al., 2010a; Lecot et al., 2016; Contrepois et al., 2017).”
• Chronic inflammation and oxidative stress as a major cause of age-related diseases and cancer. (2009, background): “The relationship between chronic inflammation and many cancers has been recognized [1].”
• Four faces of cellular senescence (2011, neutral): “Inflammatory oxidative damage can also initiate carcinogenesis, and the inflammatory milieu can promote cancer by suppressing immune surveillance and/or stimulating malignant phenotypes (Allavena et al., 2008; Grivennikov et al., 2010).”
• Pulmonary Oxidative Stress, Inflammation and Cancer: Respirable Particulate Matter, Fibrous Dusts and Ozone as Major Causes of Lung Carcinogenesis through Reactive Oxygen Species Mechanisms (2013, neutral): “) [52–54].”
• The nature of myeloid-derived suppressor cells in the tumor microenvironment (2016, background): “monocyte recruitment to tumors are CCL7, CXCL8, and CXCL12 [34].”
• The inflammatory chemokines CCL2 and CCL5 in breast cancer. (2008, background): “At that time, there was a large body of evidence showing that inflammatory macrophage infiltrates in breast tumors – termed tumorassociated macrophages (TAM) – have tumor-promoting activities, exerted via their ability to release soluble mediators that promote tumor growth, angiogenesis andmatrix de”
• Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells (2011, background): “Tumor-associated macrophages that infiltrate the breast cancer stroma are the most notable migratory hematopoietic cell-type in the tumor microenvironment and function to promote the invasiveness of breast cancer cells [1-4].”
• Macrophage Polarization States in the Tumor Microenvironment (2021, background): “Indirectly, TAMs produce the enzymes plasmin, urokinase plasminogen activator, and MMP, which regulate matrix remodeling and growth factor regulation [5,113].”