Disruption of neurotransmission in Drosophila mushroom body blocks retrieval but not acquisition of memory

By M. Cowley, J. L. Smart, M. Rubinstein, Marcelo G. CerdaÂn, S. Diano, T. Horvath, Roger Cone, M. Low

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Citations in the corpus

Dopaminergic neurons write and update memories with cell-type-specific rules (2016, background): “DOI: 10.7554/eLife.16135.001”
Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila (2014, background): “The mushroom body (MB) is the main center of associative memory in insect brains (de Belle and Heisenberg, 1994, Heisenberg et al., 1985; Dubnau et al., 2001; McGuire et al., 2001).”
Recognition (2003, neutral): “…body (MB)/Kenyon cells (KCs) in insects—where sparse combinatorial codes are translated into associative memories, patterns, and behavioral decisions (de Belle & Heisenberg, 1994; Dubnau et al., 2001; Heisenberg et al., 1985; McGuire et al., 2001; Davison & Ehlers, 2011; Miyamichi et al., 2011).”
The neuronal architecture of the mushroom body provides a logic for associative learning (2014, background): “DOI: 10.7554/eLife.04577 2 of 47 Research article Dubnau et al., 2001; McGuire et al., 2001), an associative center in the protocerebrum (Figure 1 and Video 1).”
WRITING MEMORIES WITH LIGHT-ADDRESSABLE REINFORCEMENT CIRCUITRY (2009, background): “An increase in cAMP levels coincident with odor-evoked activity is thought to modify KC output synapses (Dubnau et al., 2001; McGuire et al., 2001; Heisenberg, 2003; Davis, 2005; Keene and Waddell, 2007).”
D1 Dopamine Receptor dDA1 Is Required in the Mushroom Body Neurons for Aversive and Appetitive Learning in Drosophila (2007, background): “Moreover, synaptic output of different MB lobes is involved in memory formation or retrieval in aversive and appetitive conditioning (Dubnau et al., 2001; McGuire et al., 2003; Schwaerzel et al., 2003; Isabel et al., 2004; Krashes et al., 2007).”
Different Kenyon Cell Populations Drive Learned Approach and Avoidance in Drosophila (2013, background): “1Centre for Neural Circuits and Behaviour, The University of Oxford, Tinsley Building, Mansfield Road, Oxford OX1 3SR, UK 2Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA *Correspondence: scott.waddell@cncb.ox.ac.uk http://dx.do”
Genetic manipulation of genes and cells in the nervous system of the fruit fly (2011, background): “The acute temporal control afforded by UAS-Shibirets1 allows investigation of neurons in adult behavior and even discrimination between neurons involved in learning and memory retrieval (Waddell et al., 2000; Dubnau et al., 2001; McGuire et al., 2001; Kasuya et al., 2009).”
Specific requirement of NMDA receptors for long-term memory consolidation in Drosophila ellipsoid body (2007, background): “, and synaptic output from the mushroom body is required specifically for its retrieval, but not its acquisitio”
Induction of aversive learning through thermogenetic activation of Kenyon cell ensembles in Drosophila (2014, background): “…learning and the retrieval of short-term memory (Heisenberg et al., 1985; De Belle and Heisenberg, 1994; Connolly et al., 1996; Zars et al., 2000; Dubnau et al., 2001; McGuire et al., 2001; Heisenberg, 2003; Gerber et al., 2004; Davis, 2005; Fiala, 2007; Krashes et al., 2007; Qin et al., 2012).”
Genetic dissection of neural circuits. (2008, unknown): “In Drosophila, shibirets has been used to dissect the circuits underlying memory formation, courtship behavior, and olfactory processing (Waddell et al., 2000; Dubnau et al., 2001; McGuire et al., 2001; Manoli et al., 2005; Stockinger et al., 2005).”
Postsynaptic plasticity of cholinergic synapses underlies the induction and expression of appetitive and familiarity memories in Drosophila (2022, result): “Consistent with previous reports (Dubnau et al., 2001; McGuire et al., 2001; Schwaerzel et al., 2002), a slight drop in aversive memory performance (Figure 1a) was not statistically different from their genetic controls, and also observable in the permissive temperature controls (23°C; see…”
Heterosynaptic plasticity underlies aversive olfactory learning in Drosophila (2015, unknown): “…in behavioral experiments in Drosophila, flies still learn effectively when synaptic output of a/b and g KCs is blocked during CS-US pairing (Dubnau et al., 2001; Krashes et al., 2007; McGuire et al., 2001), which suggests the existence of a plasticity-induction mechanism that does not…”
Testing odor response stereotypy in the Drosophila mushroom body. (2008, unknown): “…there (Han et al., 1992; Nighorn et al., 1991), experience can induce substantial structural changes to the MB (Heisenberg et al., 1995; Technau, 1984), and interfering with the function of the MB prevents memory formation or retrieval (Dubnau et al., 2001; McGuire et al., 2003; Zars et al., 2000).”
Neuronal assemblies of the Drosophila mushroom body (2008, background): “Temporal inhibition of the chemical synapses of the MB-associated neurons showed the requirement of these neurons for memory acquisition, stabilization, and retrieval (Dubnau et al., 2001; Waddell et al., 2000; McGuire et al., 2001; Schwaerzel et al., 2002; Krashes et al., 2007).”
Activity of Defined Mushroom Body Output Neurons Underlies Learned Olfactory Behavior in Drosophila (2015, background): “In contrast, disrupting the mushroom body has long been known to impair learned responses (Heisenberg et al., 1985; Dubnau et al., 2001; McGuire et al., 2001; Schwaerzel et al., 2002), consistent with the MB being critical for odor memory (Heisenberg, 2003).”
A Drosophila model for alcohol reward (2011, background): “, and store the associations in the specific neurons that are activated by a particular odo”