Testing odor response stereotypy in the Drosophila mushroom body.

By Mala Murthy, Ila Rani Fiete, Gilles Laurent. 2008

174 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Ecology, Evolution, Behavior and Systematics, Genetics

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Citations in the corpus

Re-evaluating circuit mechanisms underlying pattern separation (2019, positive): “Projection neurons integrate signals from stereotyped sets of glomeruli, which form random synaptic connections onto Kenyon cells in the mushroom body calyx (Figure 2B) (Masuda-Nakagawa et al., 2005; Murthy et al., 2008; Caron et al., 2013; but see Eichler et al., 2017; Zheng et al., 2018).”
Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila (2014, background): “…cells (KCs), the neurons whose parallel axonal fibers form the MB lobes (Crittenden et al., 1998; Aso et al., 2009), are not stereotyped (Figure 1A) (Murthy et al., 2008; Caron et al., 2013); that is, individual flies show distinct wiring patterns between projection neurons and KCs. Sparse…”
The neuronal architecture of the mushroom body provides a logic for associative learning (2014, background): “4 inputs from a random combination of glomeruli; that is, knowledge of a single input to a KC provides no information about the identity of the additional inputs, and connections differ in different flies (Murthy et al., 2008; Caron et al., 2013; Gruntman and Turner, 2013).”
Different Kenyon Cell Populations Drive Learned Approach and Avoidance in Drosophila (2013, unknown): “In contrast, NP7175 expresses in abc neurons and c708a in abp neurons (Murthy et al., 2008; Tanaka et al., 2008; Lin et al., 2007).”
Different classes of input and output neurons reveal new features in microglomeruli of the adult Drosophila mushroom body calyx (2012, background): “Moreover, variation in KC responses indicates the lack of circuit stereotypy between microglomeruli (Murthy et al., 2008), so that not all elements of the circuits we find here may exist in other microglomeruli.”
Olfactory information processing in Drosophila. (2009, unknown): “results are consistent with broad activation of synaptic inputs by projection neurons, and sparse spiking responses observed using electrophysiological methods in locust and Drosophila [57,92, 95 ].”
Representations of odor in the piriform cortex. (2009, unknown): “A similar organization may be operative in insects where stereotyped connections to the protocerebrum mediate innate olfactory responses, whereas it has been argued that random inputs to the mushroom body mediate learned olfactory behavior (Jortner et al., 2007; Murthy et al., 2008).”
Driving opposing behaviors with ensembles of piriform neurons. (2011, background): “A second branch projects to the mushroom body, a structure that may receive random convergent input and is required for learned olfactory responses (Marin et al., 2002; Murthy et al., 2008; Wong et al., 2002).”
Cellular-resolution population imaging reveals robust sparse coding in the Drosophila Mushroom Body (2011, background): “Although the spatial precision is certainly not to the level of individual KCs (Murthy et al., 2008), it is nevertheless conceivable that nearby KCs will have similar tuning curves.”
The complete connectome of a learning and memory centre in an insect brain (2017, background): “Previous analyses in adults 16;17 and larvae 14 suggest that the connectivity between olfactory PNs and KCs is random, but they do not eliminate the possibility of some degree of bilateral symmetry, which requires access to the full PN → KC wiring diagram in both hemispheres.”
A connectome of a learning and memory center in the adult Drosophila brain (2017, background): “Thus, only a small subset of KCs respond to a given sensory stimulus (Perez-Orive et al., 2002; Turner et al., 2008; Honegger et al., 2011; Murthy et al., 2008).”
Neuronal mechanisms underlying innate and learned olfactory processing in Drosophila. (2019, background): “This connectivity is not stereotyped [58,59], but is 178 also not purely stochastic, as PNs with similar odor tuning profiles, and from the same 179 glomeruli, tend to converge on the same KCs [57,60].”
Optimal degrees of synaptic connectivity (2017, unknown): “, 2014) and by Kenyon cells, the granule-cell analogs of the mushroom body, are a random subset of the afferents to these structures (Murthy et al., 2008; Caron et al., 2013; Gruntman and Turner, 2013).”
Pain-relief learning in flies, rats, and man: basic research and applied perspectives (2014, background): “However, the assumed strong and persistent spiking activity has not been observed in Drosophila Kenyon cells; rather, it turns out that these cells fire strikingly few spikes at the beginning and/or at the end of odor presentation (Murthy et al. 2008; Turner et al. 2008; for moth Kenyon cells, see I”