Heterosynaptic plasticity underlies aversive olfactory learning in Drosophila
By Toshihide Hige, Yoshinori Aso, M. Modi, Gerald M. Rubin, Glenn C. Turner. 2015
329 citations recorded by the source corpus.
Summary Although associative learning has been localized to specific brain areas in many animals, identifying the underlying synaptic processes in vivo has been difficult. Here, we provide the first demonstration of long-term synaptic plasticity at the output site of the Drosophila mushroom body. Pairing an odor with activation of specific dopamine neurons induces both learning and odor-specific synaptic depression. The plasticity induction strictly depends on the temporal order of the two stimuli, replicating the logical requirement for associative learning. Furthermore, we reveal that dopamine action is confined to and distinct across different anatomical compartments of the mushroom body lobes. Finally, we find that overlap between sparse representations of different odors defines both stimulus-specificity of the plasticity and generalizability of associative memories across odors. Thus, the plasticity we find here not only manifests important features of associative learning but also provides general insights into how a sparse sensory code is read out.
Subfields: Cultural Studies, Education, General Social Sciences
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Citations in the corpus
- Dopaminergic neurons write and update memories with cell-type-specific rules (2016, methodology): “In addition, the three DAN cell types, which express CsChrimson using the MB320C and MB099C drivers, have been shown to have similar spiking responses to CsChrimson activation (Hige et al., 2015).”
- Distinct dopamine receptor pathways underlie the temporal sensitivity of associative learning (2019, background): “Indeed, dopamine has been shown to bidirectionally tune the strength of KC-MBON signaling, with forward conditioning driving depression of KC-MBON synapses (Cohn et al., 2015; Hige et al., 2015; Owald et al., 2015; Séjourné et al., 2011) while strong dopamine release in the absence of odor leads to ”
- Dopamine Neurons Mediate Learning and Forgetting through Bidirectional Modulation of a Memory Trace (2018, unknown): “We chose to use electric shock in our initial experiments since it represents a true aversive stimulus to the fly, rather than using artificial methods to activate DAn (Cohn et al., 2015; Hige et al., 2015).”
- Neuronal mechanisms underlying innate and learned olfactory processing in Drosophila. (2019, background): “168 Notably, the KCs’ sparse coding scheme still allows flies to generalize learned associations 169 to similar odors (which could be viewed as noisy variations of the same odor) [52-54], a 170 property characteristic of a computer algorithm called locality-sensitive hashing, which 171 resembles KC ”
- Optimal degrees of synaptic connectivity (2017, unknown): “, 1982) and the output neurons of the Drosophila mushroom body (Hige et al., 2015).”
- Cell Type-Specific Transcriptome Analysis in the Drosophila Mushroom Body Reveals Memory-Related Changes in Gene Expression (2016, unknown): “…2014a) and that functional roles of specific cell types are being worked out in detail (Aso et al., 2014b; Chen et al., 2012; Cohn et al., 2015; Hige et al., 2015a; Hige et al., 2015b; Owald et al., 2015; Sejourne et al., 2011), our study provides a timely addition to the mushroom body…”
- Active Protection: Learning-Activated Raf/MAPK Activity Protects Labile Memory from Rac1-Independent Forgetting. (2018, unknown): “First, g neurons are believed to be a primary location for the acquisition and expression of early memory (Boto et al., 2014; Guven-Ozkan and Davis, 2014; Hige et al., 2015; Qin et al., 2012; Zhang and Roman, 2013).”
- A connectome of a learning and memory center in the adult Drosophila brain (2017, methodology): “Previous electrophysiological measurements of connectivity in the a2 compartment indicated that only about 30% of KCs connect to MBON-a2sc (Hige et al., 2015b), suggesting the possibility that the majority of KC>MBON synapses are functionally silent, as they are in cerebellar cortex, where 98% of th”