Genetic dissection of neural circuits.

By Liqun Luo, Edward M. Callaway, Karel Svoboda. Neuron, 2008

828 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/11a10cc6cc756575c8756299d5e29787ebe7b419

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In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

Citations in the corpus

The excitatory neuronal network of the C2 barrel column in mouse primary somatosensory cortex. (2009, background): “Detailed cellular-level synaptic circuit analysis of neuronal networks underlying specific sensorimotor behaviors combined with highly specific genetic manipulations (Aronoff and Petersen, 2008; Luo et al., 2008) may lead to significant progress in our sensory information, how it develops beyond P18”
Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures (2010, background): “Opsin genes can be selectively expressed in defined subsets of neurons in the brain using a variety of expression targeting strategie”
Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets (2015, background): “In most biological systems, our knowledge of cellular diversity is incomplete; for example, the cell-type complexity of the brain is unknown and widely debated (Luo et al., 2008; Petilla Interneuron Nomenclature Group, et al., 2008).”
Experience-dependent structural synaptic plasticity in the mammalian brain (2009, methodology): “It is therefore of considerable interest to probe the effects of enrichment, training, stress, drugs and lesions on dendrite structure using genetic labelling method”
Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors. (2009, neutral): “in Transgenic Mice Expressing Evolved”
Neurophysiological and Computational Principles of Cortical Rhythms in Cognition (2010, background): “Fifth, with the new targeted optogenetic manipuation that allows one to rapidly and selectively activate or d-activate a subtype of nerve cells (227, 411, 613), it is now possible to establish causal links between an observed neural activity pattern and its underlying circuit mechanism(s).”
Automated Monitoring and Analysis of Social Behavior in Drosophila (2009, background): “…in model organisms such as the nematode Caenorhabditis elegans and the fruit fly Drosophila melanogaster , thanks to the abundant genetically based tools for marking, mapping and manipulating specific populations of neurons6,7, thereby enabling large-scale genetic and functional screens8,9.”
Neural syntax: cell assemblies, synapsembles and readers (2010, positive): “…and inactivation ofmultiple single neurons and synapses by light activation are on the horizon (Boyden et al., 2005; Deisseroth et al., 2006; Luo et al., 2008; Miesenböck, 2009; Zhang et al., 2007), discussion of their potential use in identifying assemblies, neural words, and sentences is…”
Structural Properties of the Caenorhabditis elegans Neuronal Network (2009, background): “We calculate statistical and topological properties of the network, such as degree distributions, synaptic multiplicities, and small-world properties, that help in understanding network signal propagation.”
A Mammalian enhancer trap resource for discovering and manipulating neuronal cell types (2016, background): “…et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. of marker genes by BAC transgenesis or knock-in has generated useful transgenic mouse lines.”
Flow of cortical activity underlying a tactile decision in mice. (2014, background): “Themouse is a genetically tractable organism (Luo et al., 2008; O’Connor et al., 2009), providing access to defined cell types for transgene expression.”