WRITING MEMORIES WITH LIGHT-ADDRESSABLE REINFORCEMENT CIRCUITRY

By Adam Claridge‐Chang, R. Roorda, Eleftheria Vrontou, L. Sjulson, Haiyan Li, J. Hirsh, Gero Miesenböck. 2009

476 citations recorded by the source corpus.

Dopaminergic neurons are thought to drive learning by signaling changes in the expectations of salient events, such as rewards or punishments. Olfactory conditioning in Drosophila requires direct dopamine action on intrinsic mushroom body neurons, the likely storage sites of olfactory memories. Neither the cellular sources of the conditioning dopamine nor its precise postsynaptic targets are known. By optically controlling genetically circumscribed subsets of dopaminergic neurons in the behaving fly, we have mapped the origin of aversive reinforcement signals to the PPL1 cluster of 12 dopaminergic cells. PPL1 projections target restricted domains in the vertical lobes and heel of the mushroom body. Artificially evoked activity in a small number of identifiable cells thus suffices for programming behaviorally meaningful memories. The delineation of core reinforcement circuitry is an essential first step in dissecting the neural mechanisms that compute and represent valuations, store associations, and guide actions.

Subfields: Cellular and Molecular Neuroscience, Ecology, Evolution, Behavior and Systematics, Genetics, Neuroscience

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Citations in the corpus

Coordinated and Compartmentalized Neuromodulation Shapes Sensory Processing in Drosophila (2015, positive): “Distinct subsets of DANs are sufficient to drive learned olfactory associations (Aso et al., 2012; Claridge-Chang et al., 2009; Liu et al., 2012; Waddell, 2013; Yamagata et al., 2015), leading to the suggestion they may act autonomously to encode the rewarding or punishing contextual stimuli that…”
Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila (2014, background): “Recent studies of dopamine signaling have implicated distinct sites of memory formation within the MB lobes (summarized in Figure 1A) (Schroll et al., 2006; Claridge-Chang et al., 2009; Aso et al., 2010, 2012; Burke et al., 2012; Liu et al., 2012; Perisse et al., 2013).”
Dopamine Is Required for Learning and Forgetting in Drosophila (2012, positive): “, 2003), and artificial stimulation of the PPL1 DANs in the presence of an odor is sufficient to form aversive olfactory memory (Claridge-Chang et al., 2009).”
Dopamine Signalling in Mushroom Bodies Regulates Temperature-Preference Behaviour in Drosophila (2011, background): “For example, protocerebral posterior lateral 1 cluster which innervates MB is reported as routes for reinforcement and retrieval in memory formation [28,29].”
Neural syntax: cell assemblies, synapsembles and readers (2010, unknown): “Since methods for selective and fast activation and inactivation ofmultiple single neurons and synapses by light activation are on the horizon (Boyden et al., 2005; Deisseroth et al., 2006; Luo et al., 2008; Miesenböck, 2009; Zhang et al., 2007), discussion of their potential use in identifying asse”
Competing dopamine neurons drive oviposition choice for ethanol in Drosophila (2013, methodology): “The PPL1 neurons signal punishment in the context of shock-conditioned odor memory (35, 45) but also play a role in modulating sugar-conditioned odor memory (17).”
Different Kenyon Cell Populations Drive Learned Approach and Avoidance in Drosophila (2013, background): “…how specific odors are repre- sented (Turner et al., 2008; Murthy et al., 2008; Honegger et al., 2011) and reinforcement signals conveyed (Claridge-Chang et al., 2009; Aso et al., 2010, 2012; Liu et al., 2012; Burke et al., 2012), it is not known how opposing behavioral programs of avoidance or…”
A connectome of a learning and memory center in the adult Drosophila brain (2017, methodology): “Upon this representation of the sensory world, dopaminergic or octopaminergic neurons convey information of punishment or reward and induce memories that associate the sensory stimulus with its valence (Schroll et al., 2006; Schwaerzel et al., 2003; Liu et al., 2012; Burke et al., 2012; Riemensperge”
Gustatory Learning and Processing in the Drosophila Mushroom Bodies (2015, background): “…Aso et al., 2009), Tdc2–Gal4 (Cole et al., 2005), Trh–Gal4 (Sitaraman et al., 2012), tyrosine hydroxylase (TH )–Gal4 (Friggi-Grelin et al., 2003), HL9 –Gal4 (Claridge-Chang et al., 2009), UAS–shibirets (Kitamoto, 2001), OK107–Gal4 (Connolly et al., 1996), UAS–GCaMP5 (Akerboom et al., 2012),…”
Two pairs of mushroom body efferent neurons are required for appetitive long-term memory retrieval in Drosophila. (2013, background): “KCs are located at the junction between the circuit conveying olfactory information on MB calyces and the different subsets of dopaminergic neurons that mediate the signaling of aversive unconditioned stimuli (Schwaerzel et al., 2003; Claridge-Chang et al., 2009; Aso et al., 2010, 2012) or appetitiv”
cAMP signalling in mushroom bodies modulates temperature preference behaviour in Drosophila (2008, background): “For example, protocerebral posterior lateral 1 cluster which innervates MB is reported as routes for reinforcement and retrieval in memory formation [28,29].”