Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia

By Patrice D Cani, A. Neyrinck, F. Fava, C. Knauf, R. Burcelin, K. Tuohy, G. R. Gibson, N. Delzenne. Diabetologia, 2007

1,808 citations recorded by the source corpus.

Subfields: Food Science, Molecular Biology, Periodontics

View Paper: https://www.semanticscholar.org/paper/d3afe322d3d8c5a02690d471cd53c7f8a500dc3d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Food Science

1. Patrice D Cani
2. W. D. de Vos
3. C. Belzer
4. J. Walter
5. M. Derrien
6. S. Salminen
7. E. Isolauri
8. P. Calder

In Molecular Biology

1. Patrice D Cani
2. W. D. de Vos
3. F. Bäckhed
4. N. Delzenne
5. Herbert Tilg
6. J. Walter
7. C. Belzer
8. S. Salminen

Citations in the corpus

• Germ-free C57BL/6J mice are resistant to high-fat-diet-induced insulin resistance and have altered cholesterol metabolism. (2010, background): “Alternatively, many groups, including our own, have suggested that lipopolysaccharides (LPS) absorbed from gram-negative bacteria residing in the intestine may induce insulin resistance in the host (7, 8, 19).”
• Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability (2009, background): “8 33 Importantly, however, the mechanisms linking prebiotic-induced changes in gut microbiota, metabolic endotoxaemia and the improvement of obesity-related hepatic and metabolic disorders are still unknown.”
• The Impact of Diet and Lifestyle on Gut Microbiota and Human Health (2014, background): “A high fat diet also reduced cecal Bifidobacterium numbers and increased circulating LPS concentrations [128,129] and has also been shown to reduce the abundance of Clostridium cluster XIVa, including Roseburia spp.”
• Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits. (2014, positive): “Beneficial effects of dietary fiber and SCFAs have been described in several studies, all showing resistance to dietinduced obesity and increased energy expenditure (Cani et al., 2007; Gao et al., 2009; Lin et al., 2012; Neyrinck et al., 2012).”
• Impacts of Gut Bacteria on Human Health and Diseases (2015, background): “There are two types of diabetes, type-1 diabetes (T1D) and T2D.”
• The role of the gut microbiota in energy metabolism and metabolic disease. (2009, neutral): “Bifidobacterium spp [49].”
• Starving our Microbial Self: The Deleterious Consequences of a Diet Deficient in Microbiota-Accessible Carbohydrates (2014, positive): “Additional studies have linked dietary fiber and the resulting SCFAs to protection from diet-induced obesity (Cani et al., 2007; Lin et al., 2012; Neyrinck et al., 2012; Zhou et al., 2009).”
• The endocannabinoid system links gut microbiota to adipogenesis (2010, methodology): “…that in vivo colonic CB1 mRNA expression was consistently reduced in gut microbiota models known to improve gut permeability (Figure 1A, B and E) (Cani et al, 2007b, 2008, 2009) and that mice treated with a CB1 receptor antagonist exhibited improved gut permeability (Figures 2C, D and 3), we…”
• Resistant Starches Types 2 and 4 Have Differential Effects on the Composition of the Fecal Microbiota in Human Subjects (2010, background): “Not only are these microbial populations involved in the prevention of gastrointestinal infections and stimulation of the immune system, but recent research has indicated a role of the gut microbiome in complex diseases such as colon cancer, obesity, type 2 diabetes, and inflammatory bowel disease [”
• Differential Adaptation of Human Gut Microbiota to Bariatric Surgery–Induced Weight Loss (2010, result): “This is not consistent with the studies in mice that suggest a beneficial effect of Bifidobacterium species in the improvement of obesity-related metabolic and inflammatory condition (8).”