Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits.

By F. De Vadder, P. Kovatcheva-Datchary, Daisy Goncalves, J. Vinera, C. Zitoun, A. Duchampt, F. Bäckhed, G. Mithieux. Cell, 2014

1,963 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Physiology, Surgery

View Paper: https://www.semanticscholar.org/paper/db3f7c342e0f1c0e1c2f5e9f023a69789f7b8dfb

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In Endocrinology, Diabetes and Metabolism

In Physiology

In Surgery

Citations in the corpus

Starving our Microbial Self: The Deleterious Consequences of a Diet Deficient in Microbiota-Accessible Carbohydrates (2014, positive): “Butyrate appears to broadly influence metabolism and circulating propionate signals via the afferent nervous system to influence gluconeogenesis in the intestine, as well as results in improved metabolic profiles and reduced weight gain (De Vadder et al., 2014; Gao et al., 2009; Lin et al., 2012).”
The role of short-chain fatty acids in immunity, inflammation and metabolism (2020, background): “In mice, SCFAs (propionate) can increase intestinal gluconeogenesis through the intestinal-brain pathway mediated by FFAR3, which may be related to increased glucose homeostasis and weight loss (De Vadder et al. 2014; Perry et al. 2016).”
β-Hydroxybutyrate (2017, positive): “This feeds into a brain-gut signaling circuit that induces intestinal gluconeogenesis, with beneficial effects on glucose and energy homeostasis (17).”
Short‐chain fatty acids: microbial metabolites that alleviate stress‐induced brain–gut axis alterations (2018, background): “…G-protein coupled receptors (GPCRs) (Milligan et al. 2017), facilitating the secretion of various hormones (e.g. GLP-1 and PYY) and neurochemicals (e.g. serotonin) (Chambers et al. 2015; Reigstad et al. 2015), and the induction of vagus nerve signalling (De Vadder et al. 2014; Li et al. 2017).”
Dietary Gut Microbial Metabolites, Short-chain Fatty Acids, and Host Metabolic Regulation (2015, background): “Propionate and butyrate activate intestinal gluconeogenesis via a gut-brain neural circuit, thereby promoting metabolic benefits on body weight and glucose control [31].”
Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism (2016, background): “Recently, evidence has also emerged for a homeostatic signal in the hepatic portal system derived from increased intestinal gluconeogenesis from propionate which involves induction of gluconeogenic genes by butyrate.(45,46) Given the concomitant exposure of the epithelium to butyrate and propionate,”
Impact of the gut microbiota on inflammation, obesity, and metabolic disease (2016, background): “It is important to note that although SCFAs are a source of calories for the host, their intestinal production has been mostly associated with reduced inflammation and increased satiety and with overall positive metabolic effects [32, 48].”
The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication (2020, background): “Effects on brown adipose tissue activation (89), regulation of liver mitochondrial function (90), whole-body energy homeostasis (91), and control of appetite (89) and sleep (10) have been attributed to all SCFAs.”
Role of intestinal microbiota and metabolites on gut homeostasis and human diseases (2017, background): “Intestinal IGN is known to mediate host glucose and energy homeostasis [45].”