Co-evolution of tumor cells and their microenvironment.

By K. Polyak, I. Haviv, I. Campbell. Trends in Genetics, 2009

658 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/d36b3d68ff6ae8096264b928adf636953093e03b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. D. Hanahan
2. R. Weinberg
3. Zena Werb
4. Stephanie Alexander
5. Peter Friedl
6. M. Egeblad
7. E. Nakasone
8. A. Mantovani

In Molecular Biology

1. Zena Werb
2. D. Hanahan
3. R. Weinberg
4. M. Egeblad
5. E. Nakasone
6. Stephanie Alexander
7. Peter Friedl
8. A. Sica

In Oncology

1. D. Hanahan
2. R. Weinberg
3. Zena Werb
4. A. Mantovani
5. P. Allavena
6. A. Sica
7. M. Egeblad
8. E. Nakasone

Citations in the corpus

• Hallmarks of cancer: the next generation. (2011, positive): “…complemented by similar diagrams charting the complex interactions between the neoplastic and stromal cells within a tumor and the dynamic extracellular matrix that they collectively erect and remodel (Ege-blad et al., 2010; Kessenbrock et al., 2010; Pietras and Ostman, 2010; Polyak et al., 2009).”
• Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. (2009, background): “Moreover, loss of heterozygosity, changes in gene copy number of certain loci and somatic mutations in key tumor suppressor genes, including PTEN and p53, are found in the genomes of tumor-associated stromal cells [177-179].”
• Tumors as organs: complex tissues that interface with the entire organism (2010, positive): “A major question is whether these differences occur because of altered gene expression induced by the microenvironment or if some changes are caused by mutations (Polyak et al., 2009).”
• Cancer stem cells: impact, heterogeneity, and uncertainty. (2012, background): “Differences can also arise among cancer cells through extrinsic mechanisms in which different microenvironments within a tumor confer phenotypic and functional differences upon cancer cells in different locations (Figure 1B) (Polyak et al., 2009; Bissell and Hines, 2011).”
• Tumor heterogeneity: causes and consequences (2009, background): “The importance of the ecological perspective to human tumors may be highlighted by blooming studies on the tumormicroenvironment, as it is increasingly clear that understanding alterations within tumor cells is only part of the picture, and we need to understand interactions between tumors and their”
• Cancer invasion and the microenvironment: plasticity and reciprocity. (2011, positive): “Over time, the changes driving adaptive reprogramming of tumor cells and the reactive tumor stroma thus lead to a kinetic, ever-changing coevolution of the tumor with its environment (Hanahan and Weinberg, 2011; Polyak et al., 2009).”
• Pericytes: developmental, physiological, and pathological perspectives, problems, and promises. (2011, background): “It is now acknowledged that the tumor stroma is an essential component of tumor growth, invasiveness, and promotion of tumor dissemination (Joyce and Pollard, 2009; Polyak et al., 2009).”
• Tumor entrained neutrophils inhibit seeding in the premetastatic lung (2011, positive): “…of extracellular matrix components, bone marrow derived cells, fibroblasts, and other cell types (McAllister and Weinberg, 2010) and the function of these cells is modified by the malignant cells to generate a favorable environment for tumor initiation and progression (Polyak et al., 2009).”