Tumor entrained neutrophils inhibit seeding in the premetastatic lung

By Z. Granot, E. Henke, E. Comen, T. King, Larry Norton, R. Benezra. Cancer Cell, 2011

757 citations recorded by the source corpus.

Primary tumors have been shown to prepare distal organs for later colonization of metastatic cells by stimulating organ-specific infiltration of bone marrow derived cells. Here we demonstrate that neutrophils accumulate in the lung prior to the arrival of metastatic cells in mouse models of breast cancer. Tumor-entrained neutrophils (TENs) inhibit metastatic seeding in the lungs by generating H2O2 and tumor secreted CCL2 is a critical mediator of optimal anti-metastatic entrainment of G-CSF-stimulated neutrophils. TENs are present in the peripheral blood of breast cancer patients prior to surgical resection but not in healthy individuals. Thus, while tumor-secreted factors contribute to tumor progression at the primary site, they concomitantly induce a neutrophil-mediated inhibitory process at the metastatic site.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/cda93bfc2eab0bf7689e80321da121500976886c

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Citations in the corpus

EMERGING BIOLOGICAL PRINCIPLES OF METASTASIS (2017, neutral): “For example, primary tumors can educate neutrophils via CCL2 secretion, giving rise to tumor-entrained neutrophils (TENs) (Granot et al., 2011).”
Coordinated regulation of myeloid cells by tumours (2012, result): “In contrast to these observations, a recent study demonstrated that, in mice bearing 4T1 breast tumours, neutrophils inhibited the formation of tumour metastases through direct antitumour effects mediated by reactive oxygen species (ROS”
Origins of tumor-associated macrophages and neutrophils (2012, background): “Also, neutrophils in tumor-bearing subjects can act to eliminate disseminated tumor cells, and thus provide antimetastatic protection (9).”
Tumor associated macrophages and neutrophils in cancer. (2013, background): “The authors proposed that tumor entrained neutrophils (TEN) recruited in the premetastatic lung prevented tumor cell seeding through an H2O2-dependent mechanism (Granot et al. 2011).”
Roles of the immune system in cancer: from tumor initiation to metastatic progression (2018, background): “The role of CCL2 in cancer is more controversial, as previous studies have shown contradictory findings (Rollins and Sunday 1991; Manome et al. 1995; Lu and Kang 2009; Takahashi et al. 2009; Granot et al. 2011; Qian et al. 2011; Bonapace et al. 2014; Espinosa et al. 2014; Headley et al. 2016; Long e”