Cancer stem cells: impact, heterogeneity, and uncertainty.

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Evolution of the cancer stem cell model. (2014, result): “Sorted T-IC enriched populations generated non-T-IC, but some studies found that sorted non-T-IC populations could generate T-IC (Gupta et al., 2011; Magee et al., 2012; Sharma et al., 2010).”
Glioblastoma Stem Cells Generate Vascular Pericytes to Support Vessel Function and Tumor Growth (2013, neutral): “stem cell (CSC) model remains controversial for some tumor types (Magee et al., 2012).”
Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma (2013, background): “…predominantly MES/ CIMP GBMs. Placement of these PN/CIMP+ GSCs in intracranial xenografts did not restore the MES phenotype of the parental tumor, indicating a potential shortcoming of immunocompromised xenograft models to fully recapitulate the human tumor microenvironment (Magee et al., 2012).”
iNOS promotes CD24+CD133+ liver cancer stem cell phenotype through a TACE/ADAM17-dependent Notch signaling pathway (2018, background): “H carcinoma (HCC) is closely associated with chronic inflammation, accumulation of genetic changes, alterations of the liver microenvironment, and generation of liver cancer stem cells (LCSCs) (1).”
BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells (2013, background): “Indeed, key stem cell properties such as self-renewal are readily evident in stem cells from multiple tumor types (Magee et al., 2012).”