Autophagic programmed cell death by selective catalase degradation.

By Li Yu, F. Wan, S. Dutta, S. Welsh, Zhihua Liu, E. Freundt, Eric H. Baehrecke, M. Lenardo. Proceedings of the National Academy of Sciences of the United States of America, 2006

711 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/d2b2dfdd1b4b698b215ae6d572bdaa69e0195feb

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Citations in the corpus

Cell death in the nervous system (2006, background): “, which has been proposed to be mediated by the selective degradation of catalas”
Direct induction of autophagy by Atg1 inhibits cell growth and induces apoptotic cell death. (2007, background): “In this regard, it was recently shown that the caspase-inhibitor zVAD results in targeted autophagic degradation of catalase, leading to accumulation of radical oxygen species and death [16].”
Autophagic cell death: the story of a misnomer (2008, background): “Autophagy might disrupt the pro-death–anti-death equilibrium, for instance by the selective removal of antioxidant enzymes, such as catalas”
Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury. (2008, background): “It has also been suggested that inhibition of caspases promotes necrotic cell death (264), and autophagy (284).”
Neuronal Cell Death. (2018, neutral): “However, this death did not require fusion with lysosomes, or at least lysosomal activity, so it was not dependent on a complete autophagic flux, and this death was not mediated by autophagic elimination of catalase, as had previously been found in apoptosis-deficient (Bax/Bak knockout) cells (779).”
Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells (2008, background): “The degradation of catalase is mediated by autophagy indicating a role for autophagy in caspase-independent cell death.(15) Furthermore, ROS contribute to caspase-independent cell death in macrophages.”
Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4 (2007, neutral): “In that study, however, starvation did not lead to a similar effect (Yu et al, 2006).”
Catalase function in plants: a focus on Arabidopsis mutants as stress-mimic models. (2010, background): “Selective degradation of catalase was reported to be a trigger of autophagic cell death in animal cells (Yu et al., 2006).”
Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway. (2008, background): “The protection offered by reducing the levels of glutathione peroxidase (gpx4) and glutathione S-transferases (gsta3 and gsto2), which is expected to increase the availability of free glutathione, is consistent with the fact that RIP1 activation leads to increases in the cellular levels of free radi”
Growth arrest and autophagy are required for salivary gland cell degradation in Drosophila. (2007, neutral): “We do not believe that this is the role of autophagy in salivary glands, as no phagocytosis is observedduringsalivaryglanddeath(MartinandBaehrecke, 2004).Alternatively, autophagymay beusedto recruit and degrade factors that promote cell survival, such as the degradation of cytoplasmic catalase in mo”
Cardiac autophagy is a maladaptive response to hemodynamic stress. (2007, background): “Autophagy is a mechanism required for normal development and, depending on the context, an adaptive response to stress; in other settings, autophagy is maladaptive, contributing to disease pathogenesis and cell death (19, 27, 28).”