Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway.

By J. Hitomi, Dana E Christofferson, Aylwin Ng, Jianhua Yao, Alexei Degterev, Ramnik J. Xavier, Junying Yuan. Cell, 2008

1,009 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/46a5716371e549f09ef1cec8b9efe5b352801c87

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Guido Kroemer
2. L. Galluzzi
3. S. Ghosh
4. M. Hayden
5. L. Zitvogel
6. Simone Fulda
7. Junying Yuan
8. Oliver Kepp

In Molecular Biology

1. Guido Kroemer
2. Douglas R. Green
3. L. Galluzzi
4. Beth Levine
5. Simone Fulda
6. D. Tang
7. Junying Yuan
8. D. Klionsky

Citations in the corpus

• Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications (2021, background): “The cylindromatosis (CYLD) protein can deubiquitinate RIPK1, which is essential for necrosome formation in TNF‐α‐induced necroptosis.(90) Besides, CYLD is also a substrate for proteolysis by caspase‐8, and caspase‐8 inhibits necroptosis by processing CYLD.”
• The Development of the Concept of Ferroptosis (2018, positive): “two decades until it was widely accepted that ‘necroptosis’ should be classified as a form of regulated cell death [15,16].”
• Regulation of tumour necrosis factor signalling: live or let die (2015, background): “Another deubiquitylating enzyme that acts on RIPK1 and is crucial for shutting down TNF-induced NF-κB activation is cylindromatosis (CYLD) 68,69 .”
• Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. (2009, neutral): “The result shown here are representative of five animals. the top hit in a genome-wise siRNA screen in L929 cells for genes whose knockdown prevented TNFa-mediated necrosis (necropotosis) in these cells (Hitomi et al., 2008).”
• Mechanisms of cell protection by heme oxygenase-1. (2010, background): “In addition, engagement of death receptors such as Fas (137) or TNFR-1 can induce a form of programmed cell death related to necrosis but that shares some biochemical features of apoptosis, that is, necroptosis (138, 139).”
• Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47 (2011, methodology): “and implemented in the R programming language as describe”
• Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL* (2013, background): “IFN-primed (45) L929 fibroblasts died rapidly following TLR3 activation (Fig.”
• Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 (2018, background): “In this context, CYLD also contributes to necroptosis by deubiquitinating—and hence suppressing the anti-necroptotic activity of—TRAF2 [497].”
• Cell Death Signaling. (2015, background): “Several mechanisms have been proposed, including the generation of reactive oxygen species (either mitochondrial or via NADPH oxidase) and elevation of metabolic processes to deplete ATP and/or NADH, but the evidence for them is not compelling (Hitomi et al. 2008).”