Drosophila's insulin/PI3-kinase pathway coordinates cellular metabolism with nutritional conditions.

By Jessica S. Britton, W. K. Lockwood, Ling Li, Stephen M Cohen, Bruce Edgar. Developmental Cell, 2002

676 citations recorded by the source corpus.

Subfields: Aging, Cellular and Molecular Neuroscience, Immunology

View Paper: https://www.semanticscholar.org/paper/d1dc1a745f882e6c565934b7d84b512d454d86a7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. Jae H. Park
2. Gyunghee G. Lee

In Cellular and Molecular Neuroscience

1. Jae H. Park
2. Gyunghee G. Lee
3. R. Tjian
4. David M. Sabatini
5. D. Kodrík

In Immunology

1. Bruce Edgar
2. David M. Sabatini
3. Beth Levine

Citations in the corpus

• Direct induction of autophagy by Atg1 inhibits cell growth and induces apoptotic cell death. (2007, methodology): “through heat shock-independent induction as described [43] and in the wing disc by means of 1 hr heat shock at 37 C, 36–48 hr after hatching (elimination studies) or 30–60 min heat shock at 37 C,”
• Hemolymph Sugar Homeostasis and Starvation-Induced Hyperactivity Affected by Genetic Manipulations of the Adipokinetic Hormone-Encoding Gene in Drosophila melanogaster (2004, background): “In accordance with the prediction, hemolymph glycerol concentrations were signifi-of lipids, which are consumed rapidly upon starvation (Zinke et al. 1999; Britton et al. 2002).”
• Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway. (2003, background): “It has been shown that regulation of growth during development depends on the availability of nutrients (Britton et al. 2002) and that food limitation decreases the Drosophila insulin-like peptide (DILP) levels (Ikeya et al.”
• Growth arrest and autophagy are required for salivary gland cell degradation in Drosophila. (2007, positive): “We monitored PI3K activity during development of larval salivary glands using the phosphatidylinositol-3, 4, 5-P3 (PIP3) reporter tGPH (tubulin-GFPPleckstrin Homology) as an in vivo reporter for class I PI3K activity (Britton et al., 2002).”
• Role and regulation of starvation-induced autophagy in the Drosophila fat body. (2004, neutral): “First, starvation results in rapid inactivation of these molecules, as indicated by dephosphorylation of the TOR substrate S6K, and reduced levels of PIP3 in the plasma membrane of fat body cells (Britton et al., 2002; Oldham et al., 2000).”
• Regulation of TORC1 by Rag GTPases in nutrient response (2008, background): “As a proper response to nutrient limitation is also important for organisms to survive under unfavourable condition”
• Rheb promotes cell growth as a component of the insulin/TOR signalling network (2003, background): “Using a pleckstrin homology (PH) domain–green fluorescent protein (GFP) fusion protein as a reporter of PI(3)K activit”
• Dietary protein mediates a trade-off between larval survival and the development of male secondary sexual traits (2013, background): “…animal taxa, this metabolic signalling pathway regulates the rate of somatic tissue growth by linking the availability of dietary nutrients to cell growth and proliferation (Britton & Edgar 1998; Brogiolo et al. 2001; Britton et al. 2002; Ikeya et al. 2002; Teleman 2009; Tennessen & Thummel 2011).”
• How cells coordinate growth and division. (2004, background): “In contrast, the frequency of endocycles in the polyploid cell types that make up most of the Drosophila larva is strictly determined by cell growth [173].”
• A nutrient sensor mechanism controls Drosophila growth. (2003, background): “170, 63–70. w1118 (control in most experiments), tGPH (Britton et al., 2002), UASBritton, J.S., and Edgar, B.A. (1998).”