A nutrient sensor mechanism controls Drosophila growth.

By J. Colombani, S. Raisin, S. Pantalacci, Thomas Radimerski, J. Montagne, P. Léopold. Cell, 2003

773 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Immunology, Plant Science

View Paper: https://www.semanticscholar.org/paper/db61c5b25b903967a886d272c38b0ffd2cf7d8c7

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Citations in the corpus

Lactobacillus plantarum promotes Drosophila systemic growth by modulating hormonal signals through TOR-dependent nutrient sensing. (2011, methodology): “, 1995) and ppl-GAL4 (Colombani et al., 2003) for mild larval fat body expression and P0206-GAL4 for mild prothoracic gland expression (Janning, 1997).”
Growing roles for the mTOR pathway. (2005, background): “In addition to regulating cell size, the raptor–dTOR pathway also controls Drosophila organ and organism size by regulating cell proliferation in a non-cell-autonomous fashion [38].”
Nutrient sensing and inflammation in metabolic diseases (2008, background): “melanogaster , in which TOR signalling in the fat body modulates insulin signalling and growth in peripheral tissue”
TOR signaling in growth and metabolism. (2006, background): “Interestingly, ablation of dTOR in the fat body (the fly equivalent of liver and adipose tissue) results in a systemic defect in larval growth (Colombani et al., 2003).”
Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression (2004, background): “…cell autonomous manner, but a new publication suggests that dTOR in Drosophila may control cell growth by a non cell autonomous, humoral mechanism (Colombani et al., 2003): mutation of dTOR, mutation of an aminoacid transporter known as slimfast, or overexpression of TSC1/2 in an organ called the…”
Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. (2004, positive): “In Drosophila, the fat body has been proposed to modulate insulin signaling in peripheral tissues by secretion of dALS (acid-labile subunit) [22], which, in mammals, forms a ternary complex with insulin-like growth factor, leading to an extension of the half-life of its ligand [42].”
Role and regulation of starvation-induced autophagy in the Drosophila fat body. (2004, background): “Second, mutations that disrupt TOR or PI3K signaling phenocopy many of the effects of starvation including reduced larval growth, specific arrest of endoreplicative cell cycles, and aggregation of lipid vesicles in the fat body (Britton et al., 2002; Colombani et al., 2003; Zhang et al., 2000).”
Antioxidant Role for Lipid Droplets in a Stem Cell Niche of Drosophila (2015, neutral): “…(TOR) pathway in the fat body and activate a systemic relay signal that triggers insulin-like peptide (Ilp) expression in glia, an important niche for larval neuroblasts (Chell and Brand, 2010; Colombani et al., 2003; Dumstrei et al., 2003; Sousa-Nunes et al., 2011; Spéder and Brand, 2014).”
Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy (2009, positive): “minidiscs and slimfast function in the fat body to sense nutrient availability and control body size, the later doing so via dTOR (Colombani et al., 2003).”
Meeting the energetic demands of insect diapause: nutrient storage and utilization. (2007, background): “Much less is known about how insects perceive nutrient reserves, but it is clear that the fat body plays a dynamic role in signaling nutrient status in insects and is critical in modulating important life history traits such as longevity, metamorphic timing, body size, reproductive timing, and fecun”
Regulation of TORC1 by Rag GTPases in nutrient response (2008, background): “The Drosophila larval fat body is involved in TOR-dependent nutrient sensing, as well as in relaying a nutritional response during developmen”