Hemolymph Sugar Homeostasis and Starvation-Induced Hyperactivity Affected by Genetic Manipulations of the Adipokinetic Hormone-Encoding Gene in Drosophila melanogaster

By Gyunghee G. Lee, Jae H. Park. Genetics, 2004

608 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Ecology, Ecology, Evolution, Behavior and Systematics

View Paper: https://www.semanticscholar.org/paper/c49761d3579e16260dddac3dca8f07d8e460b752

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In Cellular and Molecular Neuroscience

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Citations in the corpus

Essential role of the mushroom body in context-dependent CO₂ avoidance in Drosophila. (2013, background): “Starvation is known to affect food searching and feeding behavior [10–12] and locomotion [13], as well as memory expression [14].”
Adipokinetic hormone functions that are not associated with insect flight (2008, methodology): “Lee & Park (2004) demonstrated that a free-running circadian rhythm of locomotory activity persists in D. melanogaster with deficient AKH cells as well as in the wild-type flies.”
Meeting the energetic demands of insect diapause: nutrient storage and utilization. (2007, background): “…van der Horst, 2003; Gäde, 2004), but recent physiological and genetic studies in D. melanogaster and Bombyx mori suggest that AKHs also play roles in nutrient homeostasis, particularly blood sugar regulation (Satake et al., 2000; Kim and Rulifson, 2004; Lee and Park, 2004; Isabel et al., 2005).”
INSECT FAT BODY: ENERGY, METABOLISM, AND REGULATION (2010, background): “Supporting a role of AKH in glycogen mobilization, ablation of AKH-producing cells in Drosophila promotes a decrease in trehalose levels in both larvae and adults (67,76,78).”
PDF cells are a GABA-responsive wake-promoting component of the Drosophila sleep circuit. (2008, unknown): “…about nutritional and metabolic state, i.e., animals undergoing starvation exhibit hyperlocomotor activity that is believed to be evolutionarily useful as a method for finding food (Lee and Park, 2004), and alteration of this pars-generated locomotor program affects sleep (Mattaliano et al., 2007).”
Brummer lipase is an evolutionary conserved fat storage regulator in Drosophila. (2005, background): “…hormone (AKH) in various species including the grasshopper Locusta migratoria (Gäde and Beenakkers, 1977), the tobacco hornworm Manduca sexta (Ziegler et al., 1990), and the fruit fly Drosophila melanogaster (Lee and Park, 2004), suggesting a general role in insect energy balance control.”