Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation

By Hania Kebir, Katharina Kreymborg, I. Ifergan, A. Dodelet-Devillers, R. Cayrol, Monique Bernard, F. Giuliani, N. Arbour, B. Becher, A. Prat. Nature Medicine, 2007

1,747 citations recorded by the source corpus.

Subfields: Immunology, Neurology

View Paper: https://www.semanticscholar.org/paper/d0c491686d390e0dfdffedd4e32222d5b6065fd7

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Citations in the corpus

Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis. (2008, background): “They have also recently been shown to migrate preferentially across a model for the blood-brain barrier.(20) In addition, IL-17 levels seem to be elevated in cerebrospinal fluid samples from MS patients, in particular in opticospinal MS patients.”
VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown (2009, background): “Confocal imaging of immunostained cultures confirmed that, in human BMVEC cultures, CLN-5 and OCLN and associated proteins including ZO-1 and cingulin localized to plasma membrane in areas of cell-cell contact (Fig.”
The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt (2008, background): “, where they seem to contribute to disruption of the blood-brain barrie”
IL-17 and Th17 Cells. (2009, background): “IL-22 may promote the breach of the blood-brain barrier in T cell–mediated CNS autoimmunity (127).”
Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease. (2008, background): “In line with this, it has recently been shown that Th17 cells have the potential of killing neurons, probably through the granzyme B cytolytic enzyme system (46).”
Functional morphology of the blood-brain barrier in health and disease (2018, background): “IL-17 and IL-22 cytokines produced by Th17 cells disrupt BBB tight junctions in vitro and in vivo [57].”
The biological functions of T helper 17 cell effector cytokines in inflammation. (2008, neutral): “A recent study shows that IL-17-and IL-22-expressing human Th17 cells cross the blood-brain barrier efficiently, and both IL-17 and IL-22 promote the disruption of the blood-brain barrier in vitro and in vivo (Kebir et al., 2007).”
Mechanism of Action of Oral Fingolimod (FTY720) in Multiple Sclerosis (2010, background): “Production of IL-17 and enrichment of Th17 has been noted in active MS lesions,(78) and data from human in vitro models have shown that Th17 cells migrate across the BBB, disrupt BBB tight junctions, and promote CNS inflammation through lymphocyte recruitment.(73,79) In addition, Th17 cells produce ”