A ubiquitin ligase complex assembles linear polyubiquitin chains

By T. Kirisako, Kiyoko Kamei, S. Murata, Michiko Kato, Hiromi Fukumoto, Masato Kanie, S. Sano, F. Tokunaga, Keiji Tanaka, K. Iwai. EMBO Journal, 2006

822 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d0c1caf47e32992528d5cb3be34370888cd20d2c

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Citations in the corpus

• Ubiquitination and selective autophagy (2012, background): “Conjugation on its amino terminal methionine (M1) moieties leads to the formation of linear chains.(13) ‘Classical’ K48 ubiquitin chains”
• Regulation of NF-κB by TNF Family Cytokines (2014, background): “Overexpression of the LUBAC complex activates NF-κB [97] and LUBAC co-purifies with TNFR1 complex I [98].”
• Type I interferon inhibits interleukin-1 production and inflammasome activation. (2011, methodology): “Thus, this complex is designated as LUBAC (linear ubiquitin assembly complex) (Kirisako et al., 2006).”
• Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation. (2009, background): “In agreement with the latter hypothesis, an E3 ligase complex, LUBAC (linear ubiquitin chain assembly complex), was recently shown to regulate the canonical NF-kB pathway independently of Lys63 chains (Kirisako et al., 2006; Tokunaga et al., 2009).”
• RING domain E3 ubiquitin ligases. (2009, background): “, linked together via the N terminus) ubiquitin chains (100).”
• NF-κB, the first quarter-century: remarkable progress and outstanding questions. (2012, neutral): “(Kirisako et al. 2006).”
• Molecular discrimination of structurally equivalent Lys 63‐linked and linear polyubiquitin chains (2009, background): “However, linear linkages can also be assembled by an E3 ligase complex known as the linear ubiquitin chain assembly complex (LUBAC”
• Regulation of tumour necrosis factor signalling: live or let die (2015, background): “LUBAC consists of three proteins: haeme-oxidized IRP2 ubiquitin ligase 1 (HOIL1; also known as RBCK1), HOIL1-interacting protein (HOIP; also known as RNF31) and SHANK-associated RH domain-interacting protein SHARPIN 41,42,45–47 .”