Regulation of NF-κB by TNF Family Cytokines

By M. Hayden, S. Ghosh. Seminars in Immunology, 2014

1,009 citations recorded by the source corpus.

The NF-κB family of inducible transcription factors is activated in response to a variety of stimuli. Amongst the best-characterized inducers of NF-κB are members of the TNF family of cytokines. Research on NF-κB and TNF have been tightly intertwined for more than 25 years. Perhaps the most compelling examples of the interconnectedness of NF-κB and the TNF have come from analysis of knock-out mice that are unable to activate NF-kB. Such mice die embryonically, however, deletion of TNF or TNFR1 can rescue the lethality thereby illustrating the important role of NF-κB as the key regulator of transcriptional responses to TNF. The physiological connections between NF-κB and TNF cytokines are numerous and best explored in articles focusing on a single TNF family member. Instead, in this review, we explore general mechanisms of TNF cytokine signaling, with a focus on the upstream signaling events leading to activation of the socalled canonical and noncanonical NF-κB pathways by TNFR1 and CD40 respectively.

Subfields: Cancer Research, Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/535eb70d2fc32e8961abd0590dbc45b89f863ba5

Citations in the corpus

• Silymarin as a Natural Antioxidant: An Overview of the Current Evidence and Perspectives (2015, neutral): “The resulting release of NF-κB and subsequent translocation to the nucleus orchestrates the transcription of target genes, responsible for cell survival and involved with inflammation, immunity, apoptosis, cell proliferation and differentiation [209].”