Regulation of tumour necrosis factor signalling: live or let die

By D. Brenner, Heiko Blaser, T. Mak. Nature reviews. Immunology, 2015

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Necroptosis: Mechanisms and Relevance to Disease (2016, neutral): “The ultimate outcome of TNF signaling, however, exhibits an elevated degree of context dependency, ranging from the cytoprotective and proinflammatory activation of NF-κ B-dependent transcriptional programs to RCD via CASP8-and CASP3-mediated apoptosis or RIPK3-and MLKL-dependent necroptosis (55).”
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 (2018, background): “, intensity and duration of TNF stimulation) factors [283].”
The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics (2021, background): “The activation of TNFR1 can trigger the formation of different signaling complexes, referred to as complexes I, IIa, IIb, and IIc, which result in distinct cellular responses [11,12].”