RING domain E3 ubiquitin ligases.

By R. Deshaies, C. Joazeiro. Annual Review of Biochemistry, 2009

2,688 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/bad3f08c363426e09b0089582deb2cecfa364e86

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. C. Crews
2. George M. Burslem
3. Wenyi Wei
4. D. C. Chan
5. C. Lima
6. M. B. Metzger
7. Lei Chen
8. Michael J. Sweredoski

In Oncology

1. C. Crews
2. George M. Burslem
3. C. Lima
4. A. Weissman
5. Y. Ye
6. M. Rapé
7. Jaclyn R. Gareau

Citations in the corpus

• Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences (2012, neutral): “…from an E2 conjugating enzyme at a cysteine residue within the HECT domain to form a thioester, whereas RING-type ligases act as bridging proteins that bring the ubiquitin-charged E2 in close proximity to the substrate, but are not ubiquitinated themselves (reviewed in Deshaies and Joazeiro, 2009).”
• The role of ubiquitination in tumorigenesis and targeted drug discovery (2020, background): “An E3 can bind directly to the substrate without the assistance of other proteins in catalyzing the ubiquitination of the substrate.(58,59) For example, Mdm2 (murine double minute2)/Hdm2 (HDM2 being the human enzyme) and RNF152 (ring finger protein 152) belong to this class of E3s.”
• HECT and RING finger families of E3 ubiquitin ligases at a glance (2012, background): “The vast majority of E3 ligases belong to the group of really interesting new gene (RING) and RING-related E3s – such as plant homeodomain (PHD) and leukemia associated protein (LAP) finger proteins, and members of the U-box family (Deshaies and Joazeiro, 2009).”
• The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition (2010, background): “Although it is unclear whether automodification represents a general mechanism to regulate SUMO E3 ligases, it is attractive to consider because E3 automodification is a common theme for the regulation of E3 enzymes in the ubiquitin pathwa”
• ncRNA- and Pc2 Methylation-Dependent Gene Relocation between Nuclear Structures Mediates Gene Activation Programs (2011, neutral): “CDCA7L possesses a conserved RING finger domain, a characteristic of RING-class E3 ubiquitin protein ligases (Deshaies and Joazeiro, 2009).”