Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging

By A. Krtolica, S. Parrinello, S. Lockett, P. Desprez, J. Campisi. Proceedings of the National Academy of Sciences of the United States of America, 2001

1,660 citations recorded by the source corpus.

Subfields: Physiology

View Paper: https://www.semanticscholar.org/paper/cfe42fa7d6cd1b5cfd7c71aa2b2a07339be24158

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Physiology

1. J. Campisi
2. Jesús Gil
3. M. Demaria
4. Adam Freund
5. Manuel Serrano
6. F. Rodier
7. P. Desprez
8. C. Patil

Citations in the corpus

• Stromal fibroblasts in cancer initiation and progression (2004, background): “Interestingly, senescent human fibroblasts can promote the proliferation of pre-malignant and malignant epithelial cells in culture, and the formation of tumours in mic”
• Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation (2004, methodology): “Moreover, senescent human fibroblasts can promote the proliferation and tumorigenic conversion of premalignant (non-tumorigenic, but bearing potentially oncogenic mutations), but not normal, epithelial cells in culture and in vivo (Krtolica et al., 2001).”
• The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression (2010, background): “In addition to secreted soluble factors, there is evidence that the matrix laid down by senescent cells can also stimulate mammary epithelial cell growth (13).”
• Lamin B1 loss is a senescence-associated biomarker (2012, methodology): “Cells were made replicatively senescent by repeated subculture, as described (Dimri et al., 1995; Krtolica et al., 2001).”
• Senescence is a developmental mechanism that contributes to embryonic growth and patterning. (2013, background): “In some instances, the SASP can induce proliferation or epithelial-tomesenchymal transformation (EMT) and invasion in neighboring cells, exerting protumorigenic influence (Krtolica et al., 2001; Parrinello et al., 2005).”
• A senescent cell bystander effect: senescence-induced senescence (2012, background): “Thus, senescent cells stimulated proliferation and invasiveness of premalignant and malignant epithelial cells in co-culture and co-transplantation experiments (Krtolica et al., 2001; Bavik et al., 2006; Liu & Hornsby, 2007).”
• Decoding cell death signals in liver inflammation. (2013, background): “Although this pathway associating hepatic fibrosis, senescence, and immunosurveillance has been primarily described in a model of acute liver intoxication, the immune system may similarly be involved in the development of severe or chronic liver pathologies such as cirrhosis and hepatocellular carci”
• Cellular senescence in cancer and aging. (2007, positive): “Alternatively, it has been observed that senescent cells, in contrast to normal cells, provide a better milieu and stromal support for cancer cells (Krtolica et al., 2001).”
• Inflammatory Networks during Cellular Senescence: Causes and Consequences (2010, background): “cells in culture and in vivo [37][38] (Figure 2).”