Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice.

By William L. Holland, Benjamin T. Bikman, Liping Wang, Yuguang Guan, Katherine M Sargent, Sarada Bulchand, Trina A. Knotts, G. Shui, D. Clegg, Markus R. Wenk and 3 more. Journal of Clinical Investigation, 2011

666 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/7c8b877229c2bbb2dd73d431c67943bd5240a6ff

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Citations in the corpus

Obesity and Its Metabolic Complications: The Role of Adipokines and the Relationship between Obesity, Inflammation, Insulin Resistance, Dyslipidemia and Nonalcoholic Fatty Liver Disease (2014, background): “, TNF-α and saturated fatty acids, but not unsaturated fatty acids) to the induction of insulin resistance [55,57], although the role of TNF-α in insulin resistance is somewhat controversial [59].”
INFLAMMATION AND LIPID SIGNALING IN THE ETIOLOGY OF INSULIN RESISTANCE (2012, neutral): “Many papers have demonstrated strong associations between intracellular ceramide levels and the development of insulin resistance (Holland et al., 2011; Stratford et al., 2004; Ussher et al., 2010).”
Obesity, Inflammation, Toll-Like Receptor 4 and Fatty Acids (2018, neutral): “Such a process induces the expression of mitochondrial genes that are involved with oxidative phosphorylation and with glucose capture, which is mediated by insulin [112,113].”
Cellular and Molecular Players in Adipose Tissue Inflammation in the Development of Obesity-induced Insulin Resistance (2013, critical): “A recent report showed that total body TLR4 knockout or deletion of TLR4 in the hematopoietic or non-hematopoietic compartments by BMT did not improve diet-induced insulin resistance; indeed, it actually exacerbated the insulin resistance somewhat [117].”
Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity. (2017, neutral): “One of the hallmarks of obesity in both humans and rodents is a state of chronic, unresolved inflammation in adipose tissue, liver, and possibly skeletal muscle (Hirosumi et al., 2002; Holland et al., 2011; Hotamisligil et al., 1995, 1996; Shoelson et al., 2003; Xu et al., 2003).”
Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease (2014, background): “Particular types of sphingolipids, namely ceramide and its metabolites, cause inflammation (120) and have been increasingly associated with T2D (121).”
Macrophages, immunity, and metabolic disease. (2014, background): “lacking TLR4 are protected from ceramide accumulation and insulin resistance after the infusion of saturated fatty acids (Holland et al., 2011), and treating HFDmice with myriocin, an in-”
A ceramide-centric view of insulin resistance. (2012, background): “As demonstrated in Holland et al. (2011a), recent studies revealed that ceramide is indeed an obligate intermediate linking TLR4 to the induction of insulin resistance, both in vitro and in vivo.”
Integrating Mechanisms for Insulin Resistance: Common Threads and Missing Links (2012, positive): “Palmitate infusion increases plasma cytokine concentrations, and mice lacking Toll-like receptor 4 (TLR4) are protected from ceramide accumulation and insulin resistance following lard, but not soy oil, infusions (Holland et al., 2011).”