Peroxiredoxin Evolution and the Regulation of Hydrogen Peroxide Signaling

By Z. A. Wood, Leslie B. Poole, Paul Karplus. Science, 2003

1,341 citations recorded by the source corpus.

Subfields: Materials Chemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/cecc1e01ac6a5f03c1114e0c1ce06bfecce01a5e

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In Materials Chemistry

C. Winterbourn

In Molecular Biology

Citations in the corpus

Redox-based regulation of signal transduction: principles, pitfalls, and promises. (2008, background): “Over-oxidation of Prx is believed to occur when H2O2 concentrations exceed the capacity of Prx regeneration by the Trx system, and originally was proposed to act as a “floodgate” to promote H2O2 signaling [61].”
Intracellular messenger function of hydrogen peroxide and its regulation by peroxiredoxins. (2005, background): “Intracellular messenger function of H2O2 and reversible hyperoxidation of Prxs Prokaryotic 2-Cys Prxs are insensitive to oxidative inactivation, and prokaryotes do not contain Srx [46 ,47].”
Signaling Functions of Reactive Oxygen Species (2010, background): “The sulfinic acid derivative has indeed been shown to be formed, at least in part, at the active site of Prx-2 (46, 47), but requiring a second reaction with H2O2, the reaction seems more likely to occur under severe oxidative stress than during physio-”
ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis (2007, background): “, which provides the basis for selectivity and specificit”
Antioxidants and Antioxidant Enzymes in Higher Plants (2018, background): “…2-CysPrx Monomeric CPXXXXCR motif *Refers to specific features of AtPrx IIF protein Peroxiredoxins: Types, Characteristics and Functions … 99 conformations of the active site during the catalytic cycle, designated as FF (fully folded) and LU (locally unfolded) states (Wood 2003; Cao et al. 2011).”
Metabolism and function of coenzyme Q. (2004, background): “Antioxidant enzymes include superoxide dismutase and various peroxidases such as glutathione peroxidase, catalase, thioredoxin reductase and peroxiredoxin [45,46].”
Redox chemistry of biological thiols (2010, background): “Sulfenic acids can also be further oxidized [19,108].”
Chemistry and biology of reactive oxygen species in signaling or stress responses (2011, background): “Peroxiredoxin proteins typically cycle between reduced dithiol and oxidized disulfide forms mediated by glutathione and H 2 O 2 , respectivel”