Redox-based regulation of signal transduction: principles, pitfalls, and promises.

By Y. Janssen-Heininger, B. Mossman, N. Heintz, H. Forman, B. Kalyanaraman, Toren Finkel, J. Stamler, S. Rhee, A. van der Vliet. Free Radical Biology & Medicine, 2008

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Antimicrobial strategies centered around reactive oxygen species--bactericidal antibiotics, photodynamic therapy, and beyond. (2013, background): “All these reversible oxidative changes/modifications end up changing the structure and because of that the function of the protein (Janssen-Heininger et al., 2008; Winterbourn & Hampton, 2008; Roos & Messens, 2011).”
Effects of Ionizing Radiation on Biological Molecules—Mechanisms of Damage and Emerging Methods of Detection (2014, background): “Among the cysteine modifications by ROS/RNS, cysteine nitrosation and sulfenylation are of special interest due to their reversibility and emerging roles in regulating protein function and communication (146, 160, 260, 268, 349).”
Selective Neuronal Vulnerability to Oxidative Stress in the Brain (2010, neutral): “These pathways contain redox-sensitive proteins that can undergo reversible oxidation/reduction and thus modulate their functions based on the cellular redox status (Kohr et al., 1994; Suzuki et al., 1997; Forman et al., 2002; Lipton et al., 2002; Hidalgo, 2005; Janssen-Heininger et al., 2008).”
Clinical Relevance of Biomarkers of Oxidative Stress (2015, background): “These redox signalinginduced changes, performed by reactive oxygen and nitrogen species (ROS and RNS), target protein activities within complex networks of kinases, phosphatases, ion channels, and apoptotic cascades and can cause changes in transcriptional activity (50, 53, 74, 83).”