Intracellular messenger function of hydrogen peroxide and its regulation by peroxiredoxins.

By S. Rhee, S. Kang, W. Jeong, T. Chang, Kap-Seok Yang, H. Woo. Current Opinion in Cell Biology, 2005

665 citations recorded by the source corpus.

Subfields: Biochemistry, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5a1b4bb66b93e175f8227c396c08f27858a8a920

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. N. Tonks
2. H. Forman
3. M. Jackson
4. S. Powers
5. D. Gupta
6. M. Murphy
7. J. Palma
8. Toren Finkel

In Immunology

1. Toren Finkel
2. B. Kalyanaraman
3. S. Rhee
4. H. Forman
5. N. Tonks
6. Navdeep S. Chandel
7. C. Winterbourn

In Molecular Biology

1. N. Tonks
2. M. Murphy
3. H. Forman
4. B. Kalyanaraman
5. Toren Finkel
6. S. Rhee
7. W. Moye-Rowley
8. M. Jackson

Citations in the corpus

• Novel cell death program leads to neutrophil extracellular traps (2007, neutral): “Our data show that ROS function as signaling molecules (Reth, 2002; Rhee et al., 2005; Torres et al., 2005), but the nature of the downstream signaling is still unclear.”
• Redox-based regulation of signal transduction: principles, pitfalls, and promises. (2008, background): “At least six mammalian Prx have been identified, subdivided into 2-Cys, atypical 2-Cys, and 1-Cys Prx, which exist as homodimers in different subcellular compartments ([50] for review).”
• Protein tyrosine phosphatases: from genes, to function, to disease (2006, background): “Regulation of RPTP by reversible oxidation Recently, the production of reactive oxygen species (ROS), such as hydrogen peroxide, and the resulting post-translational modification of proteins by reversible oxidation have been implicated in the regulation of tyrosine phosphorylation-dependent signa”
• How mitochondria produce reactive oxygen species (2008, background): “An interesting extension is that the activity of intramitochondrial peroxidases such as peroxiredoxins is decreased on exposure to H 2 O 2 [69– 71], and thus the mitochondrial H 2 O 2 -degradation rate may vary considerably with condition and history of the organelle.”
• Inactivation of peroxiredoxin I by phosphorylation allows localized H(2)O(2) accumulation for cell signaling. (2010, positive): “PrxI to PrxIV belong to the 2-Cys Prx subfamily of Prx enzymes, which exist as homodimers and reduce H2O2 with the use of reducing equivalents provided by thioredoxin (Trx) (Rhee et al., 2005).”
• Antioxidants and Antioxidant Enzymes in Higher Plants (2018, background): “Therefore, it has been proposed that prx1-peroxiredoxins act as floodgates that allow for local buildup of peroxide concentrations for signaling purposes (Neill et al. 2002; Wood 2003; Rhee et al. 2005; Veal et al. 2007; Karplus 2015).”
• Exercise-Induced Oxidative Stress: Cellular Mechanisms and Impact on Muscle Force Production (2008, background): “Moreover, growing evidence suggests that in addition to antioxidant properties, these peroxidases may also play a role in the regulation of H2O2 as a second messenger in receptormediated signaling (192, 328, 329).”
• The Response to Heat Shock and Oxidative Stress in Saccharomyces cerevisiae (2012, background): “There is also increasing evidence that ROS play important regulatory functions in cell signaling and thiol groups are key mediators of oxidative signal transduction (Rhee et al. 2005).”