Immune attack: the role of inflammation in Alzheimer disease

By Frank Heppner, R. Ransohoff, B. Becher. Nature Reviews Neuroscience, 2015

1,991 citations recorded by the source corpus.

Subfields: Biological Psychiatry, Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/ce908e88f74ab372dc80b0b92a459290d439e67f

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Citations in the corpus

Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly. (2017, background): “…mediated by activated microglia, reactive astrocytes and complement activation, that have been especially observed in the vicinity of amyloid plaques and even in the early stages of AD (Heppner et al., 2015; Clark et al., 2015; Heneka et al., 2015; Latta et al., 2015; Stoeck et al., 2014).”
Depression as a microglial disease. (2015, background): “Microglial activation and associated neuroinflammation evolved as an adaptive process, allowing the elimination of pathogenic challenges; however, under many circumstances, including neurodegenerative diseases such as Alzheimer's and Parkinson's diseases, activated microglia become neurotoxic and da”
High‐Dimensional Single‐Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease (2018, neutral): “These cues may be similar in geriatric and APP/PS1 mice, e.g., myelin fragmentation (Safaiyan et al., 2016), protein accumulation (David, 2012), neurodegeneration (Krasemann et al., 2017; Wyss-Coray, 2016), and/ or increased inflammatory mediators (Deleidi et al., 2015; Heppner et al., 2015).”
Reactive Astrocytes: Production, Function, and Therapeutic Potential. (2017, background): “…et al., 2012; Cekanaviciute et al., 2014), brain tumor (Jacque et al., 1978), inflammation (Zamanian et al., 2012), and a wide range of neurodegenerative diseases (Liedtke et al., 1998; Lepore et al., 2008; Kraft et al., 2013; BenHaim et al., 2015; Heppner et al., 2015; Liddelow et al., 2017).”
Unraveling the Complex Interplay Between T Cell Metabolism and Function (2018, background): “There is a growing appreciation that aberrant immune cell function underlies numerous pathologies that, even 10 years ago, were not linked to an immune component, as exemplified by Alzheimer disease (1, 2) and obesity (3, 4).”
A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease. (2017, neutral): “Some reports show that under such conditions, microglia acquire pro-inflammatory activity, which has been associated with disease escalation (Heppner et al., 2015; Tejera and Heneka, 2016; Wang et al., 2015; Yamasaki et al., 2014).”
Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution (2017, background): “In brain tissue taken at autopsy from individuals with AD, microglia surround Aβ plaques, and their altered morphology indicates that these cells are responding to challenge (Bouvier et al., 2016; Heppner et al., 2015).”
The Gut Microbiota and Alzheimer’s Disease (2017, positive): “In addition, neuroinﬂammation is regarded as a factor involved in the pathogenesis of AD (for review, see [34]).”
Glutaminyl cyclase activity correlates with levels of Aβ peptides and mediators of angiogenesis in cerebrospinal fluid of Alzheimer’s disease patients (2017, positive): “given the involvement of angiogenesis and inflammation in AD pathomechanisms [24, 29].”
Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States (2018, background): “, 2017), impaired adaptive stress response signaling (Stranahan andMattson, 2012), dysregulated neuronal Ca homeostasis (Bezprozvanny and Mattson, 2008; Stutzmann and Mattson, 2011), impaired energy metabolism (Dauncey, 2014), neuroinflammation (Heppner et al., 2015), and”