Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States
By Mark P. Mattson, T. Arumugam. Cell Metabolism, 2018
1,028 citations recorded by the source corpus.
During aging, the cellular milieu of the brain exhibits tell-tale signs of compromised bioenergetics, impaired adaptive neuroplasticity and resilience, aberrant neuronal network activity, dysregulation of neuronal Ca2+ homeostasis, the accrual of oxidatively modified molecules and organelles, and inflammation. These alterations render the aging brain vulnerable to Alzheimer’s and Parkinson’s diseases and stroke. Emerging findings are revealing mechanisms by which sedentary overindulgent lifestyles accelerate brain aging, whereas lifestyles that include intermittent bioenergetic challenges (exercise, fasting, and intellectual challenges) foster healthy brain aging. Here we provide an overview of the cellular and molecular biology of brain aging, how those processes interface with disease-specific neurodegenerative pathways, and how metabolic states influence brain health.
Subfields: Biological Psychiatry, Physiology
View Paper: https://www.semanticscholar.org/paper/5213382f66849c05c4e2b4d50f639a4251ce1cb7
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Biological Psychiatry
In Physiology
Citations in the corpus
- Evaluating large language models in theory of mind tasks (2023, background): “As illustrated by aging and degenerative brain diseases, human brains maintain many mental abilities despite significant loss of neural mass and function ( 78 ).”