Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes.

By Jer-Yuan hsu, Zu-Wen Sun, X. Li, M. Reuben, K. Tatchell, D. K. Bishop, J. Grushcow, C. Brame, J. Caldwell, Donald F. Hunt and 3 more. Cell, 2000

937 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ce800b30dcfd37fe6c74b18df70bcc6cad19df1d

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In Cell Biology

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In Molecular Biology

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Citations in the corpus

• Phosphorylation of histone H3: a balancing act between chromosome condensation and transcriptional activation. (2004, background): “Surprisingly, phosphorylation of Ser 10 in histone H3 is not required for cell-cycle progression in yeast, where phosphorylation of histone H2B might have a redundant role [ 18 ].”
• Mitotic Phosphorylation of Histone H3: Spatio-Temporal Regulation by Mammalian Aurora Kinases (2002, background): “elegans, Aurora-A does not appear to be implicated (28).”
• The cellular geography of Aurora kinases (2003, background): “This modification, which is conserved from yeast to vertebrates, is carried out by Ipl1 in budding yeas”
• Epigenetic mechanisms in memory formation (2005, background): “So far, the phosphatases PP1 and PP2A have been shown to regulate levels of phorphorylation on H3 (Ref”
• Regulation of chromatin structure by site-specific histone H3 methyltransferases (2000, background): “In contrast to the large number of described histone acetyltransferases (HATs) and histone deacetylases (HDACs), genes encoding enzymes that regulate phosphorylatio”
• Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiae. (2001, methodology): “…histone H3 mutations used to generate Figures 1C, 4, and 5B, standard PCR-based site-directed mutagenesis on the plasmid pJH18 (pRS314/HHT2-HHF2; Hsu et al. 2000) or plasmid pWZ414-F13 (pRS414/HHT2-HHT2; Zhang et al. 1998) was used to convert H3 Lys4 to Arg4 (K4R) or Ala4 (K4A), and Lys9 to…”
• The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote. (2004, background): “Although this modification can be detected at a subset of Drosophila promoters in interphase (Labrador and Corces 2003), it is highly up-regulated in the G2 phase of the cell cycle (Hsu et al. 2000).”
• Roles of Aurora Kinases in Mitosis and Tumorigenesis (2007, background): “Aurora-B Regulates Chromatin Protein Modification It has been found that Aurora-B phosphorylates histone H3 at Ser(10) and Ser(28) (51, 52) as well as its variant CENP-A at Ser(7) (53, 54) in mitosis.”
• Drosophila Aurora B Kinase Is Required for Histone H3 Phosphorylation and Condensin Recruitment during Chromosome Condensation and to Organize the Central Spindle during Cytokinesis (2001, background): “The Journal of Cell Biology, Volume 152, 2001 670 romyces cerevisiae is the aurora-related protein kinase Ipl1p (Hsu et al., 2000).”
• Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections. (2002, background): “This is indeed the1999; Hsu et al., 2000; Murnion et al., 2001).”
• A Versatile Viral System for Expression and Depletion of Proteins in Mammalian Cells (2009, neutral): “With these tools, we also demonstrated that changes in FKBPAsf1a levels did not interfere with the regulation or phosphorylation of histone H3 at serine 10 (H3Ser10) by the Aurora mitotic kinases [72].”