Regulation of chromatin structure by site-specific histone H3 methyltransferases

By S. Rea, Frank Eisenhaber, D. O’Carroll, Brian D. Strahl, Zu-Wen Sun, M. Schmid, Susanne Opravil, K. Mechtler, Chris P. Ponting, C. D. Allis and 1 more. Nature, 2000

2,960 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/84e8992ae108e7ece58d5e0dc356c6d4baf2a564

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

Citations in the corpus

Control of CpNpG DNA methylation by the KRYPTONITE histone H3 methyltransferase (2002, background): “Heterochromatin is characterized by the methylation of cytosine nucleotides of the DNA, the methylation of histone H3 at lysine 9 (H3 Lys 9), and the specific binding of heterochromatin protein 1 (HP1) to methylated H3 Lys 9 (ref”
Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. (2006, background): “…is Cell 125, 467–481, May 5, 2006 ª2006 Elsevier Inc. 467 considered a repressive mark for euchromatic genes (Nielsen et al., 2001; Shi et al., 2003) and is also one of the landmark modifications associated with heterochromatin (Nakayama et al., 2001; Peters et al., 2002; Rea et al., 2000).”
Vernalization requires epigenetic silencing of FLC by histone methylation (2004, background): “Such modifications identify silenced chromatin states in Drosophila and human cell”
A histone H3 methyltransferase controls DNA methylation in Neurospora crassa (2001, positive): “Noting that some SET proteins are protein methyltransferases, the possibility that chromatin-associated SET domain proteins are histone methyltransferases (HMTases) was examine”
RB and cell cycle progression (2006, background): “In cells lacking pRB, there is no association of me-K9-H3 in these promoters (Rea et al., 2000); in particular, these results have been developed by studying cyclin E, one of the best E2F target genes modulated by pRb.”
Hierarchical recruitment of polycomb group silencing complexes. (2004, background): “In wing imaginal discs, these PcG lysine methyltransferase (HMTase) activity (Jenuwein et proteins also are present at discrete locations at or al., 1998; Rea et al., 2000).”
RNAi-mediated chromatin silencing in fission yeast. (2008, background): “It is known that histone methyltransferases are unable to methylate target lysine residues that are acetylated, and therefore histone deacetylases (HDACs) are required to allow methylation (Rea et al. 2000).”